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NOX2 complex-derived ROS as immune regulators.
Sareila O, Kelkka T, Pizzolla A, Hultqvist M, Holmdahl R. Sareila O, et al. Among authors: kelkka t. Antioxid Redox Signal. 2011 Oct 15;15(8):2197-208. doi: 10.1089/ars.2010.3635. Epub 2011 Apr 11. Antioxid Redox Signal. 2011. PMID: 20919938 Review.
The Macrophage Mannose Receptor Regulate Mannan-Induced Psoriasis, Psoriatic Arthritis, and Rheumatoid Arthritis-Like Disease Models.
Hagert C, Sareila O, Kelkka T, Jalkanen S, Holmdahl R. Hagert C, et al. Among authors: kelkka t. Front Immunol. 2018 Feb 6;9:114. doi: 10.3389/fimmu.2018.00114. eCollection 2018. Front Immunol. 2018. PMID: 29467756 Free PMC article.
Superoxide dismutase 3 limits collagen-induced arthritis in the absence of phagocyte oxidative burst.
Kelkka T, Laurila JP, Sareila O, Olofsson P, Laukkanen MO, Holmdahl R. Kelkka T, et al. Mediators Inflamm. 2012;2012:730469. doi: 10.1155/2012/730469. Epub 2012 Mar 5. Mediators Inflamm. 2012. PMID: 22529530 Free PMC article.
Enhancement of antibody-induced arthritis via Toll-like receptor 2 stimulation is regulated by granulocyte reactive oxygen species.
Kelkka T, Hultqvist M, Nandakumar KS, Holmdahl R. Kelkka T, et al. Am J Pathol. 2012 Jul;181(1):141-50. doi: 10.1016/j.ajpath.2012.03.031. Epub 2012 May 27. Am J Pathol. 2012. PMID: 22642907
Bacillus calmette-guerin infection in NADPH oxidase deficiency: defective mycobacterial sequestration and granuloma formation.
Deffert C, Schäppi MG, Pache JC, Cachat J, Vesin D, Bisig R, Ma Mulone X, Kelkka T, Holmdahl R, Garcia I, Olleros ML, Krause KH. Deffert C, et al. Among authors: kelkka t. PLoS Pathog. 2014 Sep 4;10(9):e1004325. doi: 10.1371/journal.ppat.1004325. eCollection 2014 Sep. PLoS Pathog. 2014. PMID: 25188296 Free PMC article.
Reactive Oxygen Species Regulate Both Priming and Established Arthritis, but with Different Mechanisms.
Sareila O, Hagert C, Kelkka T, Linja M, Xu B, Kihlberg J, Holmdahl R. Sareila O, et al. Among authors: kelkka t. Antioxid Redox Signal. 2017 Dec 20;27(18):1473-1490. doi: 10.1089/ars.2016.6981. Epub 2017 Jun 1. Antioxid Redox Signal. 2017. PMID: 28467721
Mannan induces ROS-regulated, IL-17A-dependent psoriasis arthritis-like disease in mice.
Khmaladze Ia, Kelkka T, Guerard S, Wing K, Pizzolla A, Saxena A, Lundqvist K, Holmdahl M, Nandakumar KS, Holmdahl R. Khmaladze Ia, et al. Among authors: kelkka t. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3669-78. doi: 10.1073/pnas.1405798111. Epub 2014 Aug 18. Proc Natl Acad Sci U S A. 2014. PMID: 25136095 Free PMC article.
Reactive oxygen species deficiency induces autoimmunity with type 1 interferon signature.
Kelkka T, Kienhöfer D, Hoffmann M, Linja M, Wing K, Sareila O, Hultqvist M, Laajala E, Chen Z, Vasconcelos J, Neves E, Guedes M, Marques L, Krönke G, Helminen M, Kainulainen L, Olofsson P, Jalkanen S, Lahesmaa R, Souto-Carneiro MM, Holmdahl R. Kelkka T, et al. Antioxid Redox Signal. 2014 Dec 1;21(16):2231-45. doi: 10.1089/ars.2013.5828. Epub 2014 Jul 29. Antioxid Redox Signal. 2014. PMID: 24787605 Free PMC article.
Mice lacking NCF1 exhibit reduced growth of implanted melanoma and carcinoma tumors.
Kelkka T, Pizzolla A, Laurila JP, Friman T, Gustafsson R, Källberg E, Olsson O, Leanderson T, Rubin K, Salmi M, Jalkanen S, Holmdahl R. Kelkka T, et al. PLoS One. 2013 Dec 16;8(12):e84148. doi: 10.1371/journal.pone.0084148. eCollection 2013. PLoS One. 2013. PMID: 24358335 Free PMC article.
Identification of a region in p47phox/NCF1 crucial for phagocytic NADPH oxidase (NOX2) activation.
Sareila O, Jaakkola N, Olofsson P, Kelkka T, Holmdahl R. Sareila O, et al. Among authors: kelkka t. J Leukoc Biol. 2013 Mar;93(3):427-35. doi: 10.1189/jlb.1211588. Epub 2012 Dec 27. J Leukoc Biol. 2013. PMID: 23271700 Free PMC article.
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