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347 results
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Implications of endogenous roles of transporters for drug discovery: hitchhiking and metabolite-likeness.
Kell DB. Kell DB. Nat Rev Drug Discov. 2016 Feb;15(2):143. doi: 10.1038/nrd.2015.44. Nat Rev Drug Discov. 2016. PMID: 26837595 No abstract available.
Systems biology, metabolic modelling and metabolomics in drug discovery and development.
Kell DB. Kell DB. Drug Discov Today. 2006 Dec;11(23-24):1085-92. doi: 10.1016/j.drudis.2006.10.004. Epub 2006 Oct 19. Drug Discov Today. 2006. PMID: 17129827 Review.
Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?
Dobson PD, Kell DB. Dobson PD, et al. Among authors: kell db. Nat Rev Drug Discov. 2008 Mar;7(3):205-20. doi: 10.1038/nrd2438. Nat Rev Drug Discov. 2008. PMID: 18309312 Review.
'Metabolite-likeness' as a criterion in the design and selection of pharmaceutical drug libraries.
Dobson PD, Patel Y, Kell DB. Dobson PD, et al. Among authors: kell db. Drug Discov Today. 2009 Jan;14(1-2):31-40. doi: 10.1016/j.drudis.2008.10.011. Epub 2008 Dec 26. Drug Discov Today. 2009. PMID: 19049901 Review.
Implications of the dominant role of transporters in drug uptake by cells.
Dobson PD, Lanthaler K, Oliver SG, Kell DB. Dobson PD, et al. Among authors: kell db. Curr Top Med Chem. 2009;9(2):163-81. doi: 10.2174/156802609787521616. Curr Top Med Chem. 2009. PMID: 19200003 Review.
Journal club. A systems biologist ponders how disparate ideas can sometimes come together beautifully.
Kell D. Kell D. Nature. 2009 Aug 6;460(7256):669. doi: 10.1038/460669e. Nature. 2009. PMID: 19661875 No abstract available.
Predicting the points of interaction of small molecules in the NF-κB pathway.
Patel Y, Heyward CA, White MR, Kell DB. Patel Y, et al. Among authors: kell db. BMC Syst Biol. 2011 Feb 22;5:32. doi: 10.1186/1752-0509-5-32. BMC Syst Biol. 2011. PMID: 21342508 Free PMC article.
Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only.
Kell DB, Dobson PD, Oliver SG. Kell DB, et al. Drug Discov Today. 2011 Aug;16(15-16):704-14. doi: 10.1016/j.drudis.2011.05.010. Epub 2011 May 23. Drug Discov Today. 2011. PMID: 21624498
Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing.
Small BG, McColl BW, Allmendinger R, Pahle J, López-Castejón G, Rothwell NJ, Knowles J, Mendes P, Brough D, Kell DB. Small BG, et al. Among authors: kell db. Nat Chem Biol. 2011 Oct 23;7(12):902-8. doi: 10.1038/nchembio.689. Nat Chem Biol. 2011. PMID: 22020553 Free PMC article.
Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast.
Lanthaler K, Bilsland E, Dobson PD, Moss HJ, Pir P, Kell DB, Oliver SG. Lanthaler K, et al. Among authors: kell db. BMC Biol. 2011 Oct 24;9:70. doi: 10.1186/1741-7007-9-70. BMC Biol. 2011. PMID: 22023736 Free PMC article.
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