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Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver.
Nucleic Acids Res. 2016 Apr 7;44(6):2782-94. doi: 10.1093/nar/gkw112. Epub 2016 Feb 22.
Nucleic Acids Res. 2016.
PMID: 26908652
Free PMC article.
Purification of Hepatocytes and Sinusoidal Endothelial Cells from Mouse Liver Perfusion.
Cabral F, Miller CM, Kudrna KM, Hass BE, Daubendiek JG, Kellar BM, Harris EN.
Cabral F, et al. Among authors: kellar bm.
J Vis Exp. 2018 Feb 12;(132):56993. doi: 10.3791/56993.
J Vis Exp. 2018.
PMID: 29553556
Free PMC article.
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3-O sulfation of heparin leads to hepatotropism and longer circulatory half-life.
Miller CM, Xu Y, Kudrna KM, Hass BE, Kellar BM, Egger AW, Liu J, Harris EN.
Miller CM, et al. Among authors: kellar bm.
Thromb Res. 2018 Jul;167:80-87. doi: 10.1016/j.thromres.2018.05.018. Epub 2018 May 17.
Thromb Res. 2018.
PMID: 29793137
Free PMC article.
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