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The G464S amino acid substitution in Candida albicans sterol 14alpha-demethylase causes fluconazole resistance in the clinic through reduced affinity.
Kelly SL, Lamb DC, Loeffler J, Einsele H, Kelly DE. Kelly SL, et al. Biochem Biophys Res Commun. 1999 Aug 19;262(1):174-9. doi: 10.1006/bbrc.1999.1136. Biochem Biophys Res Commun. 1999. PMID: 10448088
Mode of action and resistance to azole antifungals associated with the formation of 14 alpha-methylergosta-8,24(28)-dien-3 beta,6 alpha-diol.
Kelly SL, Lamb DC, Corran AJ, Baldwin BC, Kelly DE. Kelly SL, et al. Biochem Biophys Res Commun. 1995 Feb 27;207(3):910-5. doi: 10.1006/bbrc.1995.1272. Biochem Biophys Res Commun. 1995. PMID: 7864896
The mechanism of the acyl-carbon bond cleavage reaction catalyzed by recombinant sterol 14 alpha-demethylase of Candida albicans (other names are: lanosterol 14 alpha-demethylase, P-45014DM, and CYP51).
Shyadehi AZ, Lamb DC, Kelly SL, Kelly DE, Schunck WH, Wright JN, Corina D, Akhtar M. Shyadehi AZ, et al. J Biol Chem. 1996 May 24;271(21):12445-50. doi: 10.1074/jbc.271.21.12445. J Biol Chem. 1996. PMID: 8647850
Resistance to fluconazole and amphotericin in Candida albicans from AIDS patients.
Kelly SL, Lamb DC, Kelly DE, Loeffler J, Einsele H. Kelly SL, et al. Lancet. 1996 Nov 30;348(9040):1523-4. doi: 10.1016/S0140-6736(05)65949-1. Lancet. 1996. PMID: 8942815 No abstract available.
Resistance to fluconazole and cross-resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol delta5,6-desaturation.
Kelly SL, Lamb DC, Kelly DE, Manning NJ, Loeffler J, Hebart H, Schumacher U, Einsele H. Kelly SL, et al. FEBS Lett. 1997 Jan 2;400(1):80-2. doi: 10.1016/s0014-5793(96)01360-9. FEBS Lett. 1997. PMID: 9000517
The mutation T315A in Candida albicans sterol 14alpha-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity.
Lamb DC, Kelly DE, Schunck WH, Shyadehi AZ, Akhtar M, Lowe DJ, Baldwin BC, Kelly SL. Lamb DC, et al. J Biol Chem. 1997 Feb 28;272(9):5682-8. doi: 10.1074/jbc.272.9.5682. J Biol Chem. 1997. PMID: 9038178
Characterization of Saccharomyces cerevisiae CYP51 and a CYP51 fusion protein with NADPH cytochrome P-450 oxidoreductase expressed in Escherichia coli.
Venkateswarlu K, Kelly DE, Kelly SL. Venkateswarlu K, et al. Antimicrob Agents Chemother. 1997 Apr;41(4):776-80. doi: 10.1128/AAC.41.4.776. Antimicrob Agents Chemother. 1997. PMID: 9087488 Free PMC article.
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