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The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor.
Pezet A, Buteau H, Kelly PA, Edery M. Pezet A, et al. Among authors: kelly pa. Mol Cell Endocrinol. 1997 May 16;129(2):199-208. doi: 10.1016/s0303-7207(97)00063-4. Mol Cell Endocrinol. 1997. PMID: 9202403
Identification of a gain-of-function mutation of the prolactin receptor in women with benign breast tumors.
Bogorad RL, Courtillot C, Mestayer C, Bernichtein S, Harutyunyan L, Jomain JB, Bachelot A, Kuttenn F, Kelly PA, Goffin V, Touraine P; Benign Breast Diseases Study Group. Bogorad RL, et al. Among authors: kelly pa. Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14533-8. doi: 10.1073/pnas.0800685105. Epub 2008 Sep 8. Proc Natl Acad Sci U S A. 2008. PMID: 18779591 Free PMC article.
A new mechanism for prolactin processing into 16K PRL by secreted cathepsin D.
Piwnica D, Fernandez I, Binart N, Touraine P, Kelly PA, Goffin V. Piwnica D, et al. Among authors: kelly pa. Mol Endocrinol. 2006 Dec;20(12):3263-78. doi: 10.1210/me.2006-0044. Epub 2006 Sep 7. Mol Endocrinol. 2006. PMID: 16959874
Crystal structure of an affinity-matured prolactin complexed to its dimerized receptor reveals the topology of hormone binding site 2.
Broutin I, Jomain JB, Tallet E, van Agthoven J, Raynal B, Hoos S, Kragelund BB, Kelly PA, Ducruix A, England P, Goffin V. Broutin I, et al. Among authors: kelly pa. J Biol Chem. 2010 Mar 12;285(11):8422-33. doi: 10.1074/jbc.M109.089128. Epub 2010 Jan 6. J Biol Chem. 2010. PMID: 20053995 Free PMC article.
Rational design of competitive prolactin/growth hormone receptor antagonists.
Tallet E, Rouet V, Jomain JB, Kelly PA, Bernichtein S, Goffin V. Tallet E, et al. Among authors: kelly pa. J Mammary Gland Biol Neoplasia. 2008 Mar;13(1):105-17. doi: 10.1007/s10911-008-9066-8. Epub 2008 Jan 25. J Mammary Gland Biol Neoplasia. 2008. PMID: 18219565 Review.
Medullary thyroid carcinoma arises in the absence of prolactin signaling.
Kedzia C, Lacroix L, Ameur N, Ragot T, Kelly PA, Caillou B, Binart N. Kedzia C, et al. Among authors: kelly pa. Cancer Res. 2005 Sep 15;65(18):8497-503. doi: 10.1158/0008-5472.CAN-04-3937. Cancer Res. 2005. PMID: 16166330
Development and potential clinical uses of human prolactin receptor antagonists.
Goffin V, Bernichtein S, Touraine P, Kelly PA. Goffin V, et al. Among authors: kelly pa. Endocr Rev. 2005 May;26(3):400-22. doi: 10.1210/er.2004-0016. Epub 2005 Apr 6. Endocr Rev. 2005. PMID: 15814850 Review.
A short form of the prolactin (PRL) receptor is able to rescue mammopoiesis in heterozygous PRL receptor mice.
Binart N, Imbert-Bollore P, Baran N, Viglietta C, Kelly PA. Binart N, et al. Among authors: kelly pa. Mol Endocrinol. 2003 Jun;17(6):1066-74. doi: 10.1210/me.2002-0181. Epub 2003 Mar 6. Mol Endocrinol. 2003. PMID: 12624115
Local over-expression of prolactin in differentiating mouse mammary gland induces functional defects and benign lesions, but no carcinoma.
Manhès C, Kayser C, Bertheau P, Kelder B, Kopchick JJ, Kelly PA, Touraine P, Goffin V. Manhès C, et al. Among authors: kelly pa. J Endocrinol. 2006 Aug;190(2):271-85. doi: 10.1677/joe.1.06829. J Endocrinol. 2006. PMID: 16899561
New homologous bioassays for human lactogens show that agonism or antagonism of various analogs is a function of assay sensitivity.
Bernichtein S, Jeay S, Vaudry R, Kelly PA, Goffin V. Bernichtein S, et al. Among authors: kelly pa. Endocrine. 2003 Feb-Mar;20(1-2):177-90. doi: 10.1385/ENDO:20:1-2:177. Endocrine. 2003. PMID: 12668884
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