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The G464S amino acid substitution in Candida albicans sterol 14alpha-demethylase causes fluconazole resistance in the clinic through reduced affinity.
Kelly SL, Lamb DC, Loeffler J, Einsele H, Kelly DE. Kelly SL, et al. Biochem Biophys Res Commun. 1999 Aug 19;262(1):174-9. doi: 10.1006/bbrc.1999.1136. Biochem Biophys Res Commun. 1999. PMID: 10448088
Glyphosate is an inhibitor of plant cytochrome P450: functional expression of Thlaspi arvensae cytochrome P45071B1/reductase fusion protein in Escherichia coli.
Lamb DC, Kelly DE, Hanley SZ, Mehmood Z, Kelly SL. Lamb DC, et al. Biochem Biophys Res Commun. 1998 Mar 6;244(1):110-4. doi: 10.1006/bbrc.1997.7988. Biochem Biophys Res Commun. 1998. PMID: 9514851
NADPH cytochrome P-450 oxidoreductase and susceptibility to ketoconazole.
Venkateswarlu K, Kelly DE, Manning NJ, Kelly SL. Venkateswarlu K, et al. Antimicrob Agents Chemother. 1998 Jul;42(7):1756-61. doi: 10.1128/AAC.42.7.1756. Antimicrob Agents Chemother. 1998. PMID: 9661017 Free PMC article.
A sterol biosynthetic pathway in Mycobacterium.
Lamb DC, Kelly DE, Manning NJ, Kelly SL. Lamb DC, et al. FEBS Lett. 1998 Oct 16;437(1-2):142-4. doi: 10.1016/s0014-5793(98)01218-6. FEBS Lett. 1998. PMID: 9804188
Characteristics of the heterologously expressed human lanosterol 14alpha-demethylase (other names: P45014DM, CYP51, P45051) and inhibition of the purified human and Candida albicans CYP51 with azole antifungal agents.
Lamb DC, Kelly DE, Waterman MR, Stromstedt M, Rozman D, Kelly SL. Lamb DC, et al. Yeast. 1999 Jun 30;15(9):755-63. doi: 10.1002/(SICI)1097-0061(19990630)15:9<755::AID-YEA417>3.0.CO;2-8. Yeast. 1999. PMID: 10398344
Cytochrome P450105D1 (CYP105D1) from Streptomyces griseus: heterologous expression, activity, and activation effects of multiple xenobiotics.
Taylor M, Lamb DC, Cannell R, Dawson M, Kelly SL. Taylor M, et al. Biochem Biophys Res Commun. 1999 Oct 5;263(3):838-42. doi: 10.1006/bbrc.1999.1427. Biochem Biophys Res Commun. 1999. PMID: 10512767
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