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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1854 1
1873 1
1892 1
1898 1
1899 2
1901 1
1905 1
1908 1
1909 3
1910 2
1911 3
1912 1
1913 1
1914 2
1915 2
1917 1
1918 3
1923 2
1925 1
1930 1
1931 1
1932 2
1934 3
1935 1
1936 1
1940 2
1943 1
1945 2
1946 8
1947 6
1948 7
1949 5
1950 9
1951 20
1952 11
1953 16
1954 14
1955 10
1956 16
1957 13
1958 14
1959 13
1960 11
1961 24
1962 20
1963 30
1964 35
1965 24
1966 17
1967 41
1968 32
1969 22
1970 29
1971 34
1972 34
1973 35
1974 48
1975 51
1976 53
1977 32
1978 36
1979 34
1980 26
1981 34
1982 40
1983 44
1984 45
1985 39
1986 46
1987 45
1988 42
1989 46
1990 63
1991 46
1992 51
1993 49
1994 66
1995 70
1996 67
1997 58
1998 77
1999 92
2000 84
2001 94
2002 91
2003 110
2004 117
2005 131
2006 137
2007 164
2008 176
2009 184
2010 199
2011 205
2012 229
2013 241
2014 243
2015 247
2016 246
2017 263
2018 244
2019 282
2020 347
2021 380
2022 440
2023 449
2024 470
2025 470

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7,425 results

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Page 1
Characterization of the skin keloid microenvironment.
Zhang M, Chen H, Qian H, Wang C. Zhang M, et al. Cell Commun Signal. 2023 Aug 16;21(1):207. doi: 10.1186/s12964-023-01214-0. Cell Commun Signal. 2023. PMID: 37587491 Free PMC article. Review.
Keloids are a fibroproliferative skin disorder that develops in people of all ages. Keloids exhibit some cancer-like behaviors, with similar genetic and epigenetic modifications in the keloid microenvironment. ...Recent advances in the study of keloids …
Keloids are a fibroproliferative skin disorder that develops in people of all ages. Keloids exhibit some cancer-like behaviors …
Schwann cells contribute to keloid formation.
Direder M, Weiss T, Copic D, Vorstandlechner V, Laggner M, Pfisterer K, Mildner CS, Klas K, Bormann D, Haslik W, Radtke C, Farlik M, Shaw L, Golabi B, Tschachler E, Hoetzenecker K, Ankersmit HJ, Mildner M. Direder M, et al. Matrix Biol. 2022 Apr;108:55-76. doi: 10.1016/j.matbio.2022.03.001. Epub 2022 Mar 10. Matrix Biol. 2022. PMID: 35278628 Free article.
In contrast to normal skin, keloidal Schwann cells show a unique, pro-fibrotic phenotype. Our data support the hypothesis that keloidal Schwann cells contribute to the formation of the extracellular matrix and are able to affect M2 polarization of macrophages. ...Th …
In contrast to normal skin, keloidal Schwann cells show a unique, pro-fibrotic phenotype. Our data support the hypothesis that kel …
Pruritus in Keloid Scars: Mechanisms and Treatments.
Hawash AA, Ingrasci G, Nouri K, Yosipovitch G. Hawash AA, et al. Acta Derm Venereol. 2021 Oct 28;101(10):adv00582. doi: 10.2340/00015555-3923. Acta Derm Venereol. 2021. PMID: 34518894 Free PMC article. Review.
Keloids are scars that extend beyond the margins of an insulting cutaneous injury. Keloids are often thought to be primarily a cosmetic issue, as they are typically quite raised and pigmented. ...This review describes the prevalence and importance of pruritus in …
Keloids are scars that extend beyond the margins of an insulting cutaneous injury. Keloids are often thought to be primarily a …
Keloid and Hypertrophic Scars Are the Result of Chronic Inflammation in the Reticular Dermis.
Ogawa R. Ogawa R. Int J Mol Sci. 2017 Mar 10;18(3):606. doi: 10.3390/ijms18030606. Int J Mol Sci. 2017. PMID: 28287424 Free PMC article. Review.
Moreover, proinflammatory factors, such as interleukin (IL)-1alpha, IL-1beta, IL-6, and tumor necrosis factor-alpha are upregulated in keloid tissues, which suggests that, in patients with keloids, proinflammatory genes in the skin are sensitive to trauma. This may …
Moreover, proinflammatory factors, such as interleukin (IL)-1alpha, IL-1beta, IL-6, and tumor necrosis factor-alpha are upregulated in ke …
Histopathological differential diagnosis of keloid and hypertrophic scar.
Lee JY, Yang CC, Chao SC, Wong TW. Lee JY, et al. Am J Dermatopathol. 2004 Oct;26(5):379-84. doi: 10.1097/00000372-200410000-00006. Am J Dermatopathol. 2004. PMID: 15365369
Distinguishing hypertrophic scar (HS) from keloid histopathologically is sometimes difficult because thickened hyalinized collagen (keloidal collagen), the hallmark of keloid, is not always detectable and alpha-smooth muscle actin (alpha-SMA), a differentiati …
Distinguishing hypertrophic scar (HS) from keloid histopathologically is sometimes difficult because thickened hyalinized collagen ( …
Integrated Analysis of Single-Cell and Spatial Transcriptomics in Keloids: Highlights on Fibrovascular Interactions in Keloid Pathogenesis.
Shim J, Oh SJ, Yeo E, Park JH, Bae JH, Kim SH, Lee D, Lee JH. Shim J, et al. J Invest Dermatol. 2022 Aug;142(8):2128-2139.e11. doi: 10.1016/j.jid.2022.01.017. Epub 2022 Feb 4. J Invest Dermatol. 2022. PMID: 35123990 Free article.
Keloid tissue samples and normal skin control data were analyzed as well as those of patient-matched keloid and normal mature scar. Single-cell RNA sequencing revealed cellular heterogenicity such as fibroblasts, endothelial cells (ECs), and myofibroblasts within th …
Keloid tissue samples and normal skin control data were analyzed as well as those of patient-matched keloid and normal mature …
IL-13RA2 downregulation in fibroblasts promotes keloid fibrosis via JAK/STAT6 activation.
Chao H, Zheng L, Hsu P, He J, Wu R, Xu S, Zeng R, Zhou Y, Ma H, Liu H, Tang Q. Chao H, et al. JCI Insight. 2023 Mar 22;8(6):e157091. doi: 10.1172/jci.insight.157091. JCI Insight. 2023. PMID: 36757802 Free PMC article.
Deciphering the underlying mechanism of keloid formation is essential for improving treatment outcomes. Here, we found that more macrophages were activated toward the M2 subtype in keloid dermis when compared with normal dermis. ...Collectively, this study elucidate …
Deciphering the underlying mechanism of keloid formation is essential for improving treatment outcomes. Here, we found that more macr …
Single-cell RNA sequencing reveals distinct immunology profiles in human keloid.
Feng C, Shan M, Xia Y, Zheng Z, He K, Wei Y, Song K, Meng T, Liu H, Hao Y, Liang Z, Wang Y, Huang Y. Feng C, et al. Front Immunol. 2022 Aug 3;13:940645. doi: 10.3389/fimmu.2022.940645. eCollection 2022. Front Immunol. 2022. PMID: 35990663 Free PMC article.
In this study, we systematically capture the cellular composition of keloids by the single-cell RNA sequencing technique. Our results indicated that there are significant differences in most cell types present between 12 pairs of keloid and adjacent normal tissue. W …
In this study, we systematically capture the cellular composition of keloids by the single-cell RNA sequencing technique. Our results …
Keloid disease: Review with clinical atlas. Part I: Definitions, history, epidemiology, clinics and diagnosis.
Delaleu J, Charvet E, Petit A. Delaleu J, et al. Ann Dermatol Venereol. 2023 Mar;150(1):3-15. doi: 10.1016/j.annder.2022.08.010. Epub 2022 Dec 7. Ann Dermatol Venereol. 2023. PMID: 36494213 Review.
The multiplication of keloids and hypertrophic scars in a single patient is known as keloid disease. Keloid disease is due to a familial predisposition (autosomal dominant) that preferentially affects people of non-European ancestry, especially those of sub-S …
The multiplication of keloids and hypertrophic scars in a single patient is known as keloid disease. Keloid disease is …
Identification of novel immune-related signatures for keloid diagnosis and treatment: insights from integrated bulk RNA-seq and scRNA-seq analysis.
Xiao K, Wang S, Chen W, Hu Y, Chen Z, Liu P, Zhang J, Chen B, Zhang Z, Li X. Xiao K, et al. Hum Genomics. 2024 Jul 16;18(1):80. doi: 10.1186/s40246-024-00647-z. Hum Genomics. 2024. PMID: 39014455 Free PMC article.
However, the clinical treatment of keloids still has limitations, that is, it is not effective in controlling keloids, resulting in a high recurrence rate. ...Subsequently, we constructed a novel artificial neural network molecular diagnostic model based on the tran …
However, the clinical treatment of keloids still has limitations, that is, it is not effective in controlling keloids, resulti …
7,425 results