International Workshop at the Nobel Forum, Karolinska Institutet on G protein-coupled receptors: finding the words to describe monomers, oligomers, and their molecular mechanisms and defining their meaning. Can a consensus be reached?

Terry Kenakin; Luigi F Agnati; Marc Caron; Bertil Fredholm; Diego Guidoli; Brian Kobilka; Robert W Lefkowitz; Martin Lohse; Amina Woods; Kjell Fuxe

doi:10.3109/10799893.2010.512438

International Workshop at the Nobel Forum, Karolinska Institutet on G protein-coupled receptors: finding the words to describe monomers, oligomers, and their molecular mechanisms and defining their meaning. Can a consensus be reached?

J Recept Signal Transduct Res. 2010 Oct;30(5):284-6. doi: 10.3109/10799893.2010.512438.

Authors

Terry Kenakin¹, Luigi F Agnati, Marc Caron, Bertil Fredholm, Diego Guidoli, Brian Kobilka, Robert W Lefkowitz, Martin Lohse, Amina Woods, Kjell Fuxe

Affiliation

¹ GlaxoSmithKline Research and Development, Research Triangle Park, NC 27709, USA. terry.p.kenakin@gsk.com

PMID: 20858022
DOI: 10.3109/10799893.2010.512438

Abstract

A meeting was held May 19, 2010 at the Karolinski Institute on Nomenclature in Pharmacology. This meeting occurred in conjunction with the Symposium The Changing World of G Protein Coupled Receptors: From Monomers to Dimers and Receptor Mosaics (Higher-order Oligomers) held the previous day at the Royal Swedish Academy of Science. Two broad topics of nomenclature were discussed; ligand nomenclature and the definition of 'receptor-receptor' interactions. This paper summarizes discussions on these topics along with a consensus definition of the term 'receptor-receptor' interaction.

MeSH terms

Congresses as Topic*
Humans
Protein Multimerization*
Receptors, G-Protein-Coupled* / chemistry
Receptors, G-Protein-Coupled* / metabolism
Signal Transduction / physiology
Sweden

Substances

Receptors, G-Protein-Coupled