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Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.
Andexer JN, Kendrew SG, Nur-e-Alam M, Lazos O, Foster TA, Zimmermann AS, Warneck TD, Suthar D, Coates NJ, Koehn FE, Skotnicki JS, Carter GT, Gregory MA, Martin CJ, Moss SJ, Leadlay PF, Wilkinson B. Andexer JN, et al. Among authors: kendrew sg. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4776-81. doi: 10.1073/pnas.1015773108. Epub 2011 Mar 7. Proc Natl Acad Sci U S A. 2011. PMID: 21383123 Free PMC article.
Diversity oriented biosynthesis via accelerated evolution of modular gene clusters.
Wlodek A, Kendrew SG, Coates NJ, Hold A, Pogwizd J, Rudder S, Sheehan LS, Higginbotham SJ, Stanley-Smith AE, Warneck T, Nur-E-Alam M, Radzom M, Martin CJ, Overvoorde L, Samborskyy M, Alt S, Heine D, Carter GT, Graziani EI, Koehn FE, McDonald L, Alanine A, Rodríguez Sarmiento RM, Chao SK, Ratni H, Steward L, Norville IH, Sarkar-Tyson M, Moss SJ, Leadlay PF, Wilkinson B, Gregory MA. Wlodek A, et al. Among authors: kendrew sg. Nat Commun. 2017 Oct 31;8(1):1206. doi: 10.1038/s41467-017-01344-3. Nat Commun. 2017. PMID: 29089518 Free PMC article.
Recombinant strains for the enhanced production of bioengineered rapalogs.
Kendrew SG, Petkovic H, Gaisser S, Ready SJ, Gregory MA, Coates NJ, Nur-E-Alam M, Warneck T, Suthar D, Foster TA, McDonald L, Schlingman G, Koehn FE, Skotnicki JS, Carter GT, Moss SJ, Zhang MQ, Martin CJ, Sheridan RM, Wilkinson B. Kendrew SG, et al. Metab Eng. 2013 Jan;15:167-73. doi: 10.1016/j.ymben.2012.11.001. Epub 2012 Nov 17. Metab Eng. 2013. PMID: 23164580
Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272.
Gaisser S, Kellenberger L, Kaja AL, Weston AJ, Lill RE, Wirtz G, Kendrew SG, Low L, Sheridan RM, Wilkinson B, Galloway IS, Stutzman-Engwall K, McArthur HA, Staunton J, Leadlay PF. Gaisser S, et al. Among authors: kendrew sg. Org Biomol Chem. 2003 Aug 21;1(16):2840-7. doi: 10.1039/b304022d. Org Biomol Chem. 2003. PMID: 12968333
Active-site residue, domain and module swaps in modular polyketide synthases.
Del Vecchio F, Petkovic H, Kendrew SG, Low L, Wilkinson B, Lill R, Cortés J, Rudd BA, Staunton J, Leadlay PF. Del Vecchio F, et al. Among authors: kendrew sg. J Ind Microbiol Biotechnol. 2003 Aug;30(8):489-94. doi: 10.1007/s10295-003-0062-0. Epub 2003 Jun 14. J Ind Microbiol Biotechnol. 2003. PMID: 12811585
Engineering of complex polyketide biosynthesis--insights from sequencing of the monensin biosynthetic gene cluster.
Leadlay PF, Staunton J, Oliynyk M, Bisang C, Cortés J, Frost E, Hughes-Thomas ZA, Jones MA, Kendrew SG, Lester JB, Long PF, McArthur HA, McCormick EL, Oliynyk Z, Stark CB, Wilkinson CJ. Leadlay PF, et al. Among authors: kendrew sg. J Ind Microbiol Biotechnol. 2001 Dec;27(6):360-7. doi: 10.1038/sj.jim.7000204. J Ind Microbiol Biotechnol. 2001. PMID: 11774001 Review.
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