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The autophagy inducer spermidine protects against metabolic dysfunction during overnutrition.
Liao CY, Kummert OMP, Bair AM, Alavi N, Alavi J, Miller DM, Bagga I, Schempf AM, Hsu YM, Woods Ii BD, Brown Mayfield SM, Mitchell AN, Tannady G, Talbot AR, Dueck AM, Barrera Ovando R, Parker HD, Wang J, Schoeneweis JK, Kennedy BK. Liao CY, et al. Among authors: kennedy bk. J Gerontol A Biol Sci Med Sci. 2021 Jun 1:glab145. doi: 10.1093/gerona/glab145. Online ahead of print. J Gerontol A Biol Sci Med Sci. 2021. PMID: 34060628
Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels.
Bailus BJ, Scheeler SM, Simons J, Sanchez MA, Tshilenge KT, Creus-Muncunill J, Naphade S, Lopez-Ramirez A, Zhang N, Lakshika Madushani K, Moroz S, Loureiro A, Schreiber KH, Hausch F, Kennedy BK, Ehrlich ME, Ellerby LM. Bailus BJ, et al. Among authors: kennedy bk. Autophagy. 2021 May 24:1-22. doi: 10.1080/15548627.2021.1904489. Online ahead of print. Autophagy. 2021. PMID: 34024231
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