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Nrf2 as a target for cancer chemoprevention.
Yu X, Kensler T. Yu X, et al. Mutat Res. 2005 Dec 11;591(1-2):93-102. doi: 10.1016/j.mrfmmm.2005.04.017. Epub 2005 Jul 28. Mutat Res. 2005. PMID: 16054659 Review.
Transcription factor Nrf2 maintains the basal expression of Mdm2: An implication of the regulation of p53 signaling by Nrf2.
You A, Nam CW, Wakabayashi N, Yamamoto M, Kensler TW, Kwak MK. You A, et al. Arch Biochem Biophys. 2011 Mar 15;507(2):356-64. doi: 10.1016/j.abb.2010.12.034. Epub 2011 Jan 4. Arch Biochem Biophys. 2011. PMID: 21211512
The NRF2-heme oxygenase-1 system modulates cyclosporin A-induced epithelial-mesenchymal transition and renal fibrosis.
Shin DH, Park HM, Jung KA, Choi HG, Kim JA, Kim DD, Kim SG, Kang KW, Ku SK, Kensler TW, Kwak MK. Shin DH, et al. Free Radic Biol Med. 2010 Apr 15;48(8):1051-63. doi: 10.1016/j.freeradbiomed.2010.01.021. Epub 2010 Jan 22. Free Radic Biol Med. 2010. PMID: 20096777 Free PMC article.
Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistance.
Meher AK, Sharma PR, Lira VA, Yamamoto M, Kensler TW, Yan Z, Leitinger N. Meher AK, et al. Free Radic Biol Med. 2012 May 1;52(9):1708-15. doi: 10.1016/j.freeradbiomed.2012.02.022. Epub 2012 Feb 24. Free Radic Biol Med. 2012. PMID: 22370093 Free PMC article.
Oltipraz chemoprevention trial in Qidong, People's Republic of China: unaltered oxidative biomarkers.
Glintborg B, Weimann A, Kensler TW, Poulsen HE. Glintborg B, et al. Free Radic Biol Med. 2006 Sep 15;41(6):1010-4. doi: 10.1016/j.freeradbiomed.2006.06.015. Epub 2006 Jul 4. Free Radic Biol Med. 2006. PMID: 16934685 Clinical Trial.
Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs.
Singh A, Ling G, Suhasini AN, Zhang P, Yamamoto M, Navas-Acien A, Cosgrove G, Tuder RM, Kensler TW, Watson WH, Biswal S. Singh A, et al. Free Radic Biol Med. 2009 Feb 1;46(3):376-86. doi: 10.1016/j.freeradbiomed.2008.10.026. Epub 2008 Nov 1. Free Radic Biol Med. 2009. PMID: 19027064 Free PMC article.
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases.
Cuadrado A, Rojo AI, Wells G, Hayes JD, Cousin SP, Rumsey WL, Attucks OC, Franklin S, Levonen AL, Kensler TW, Dinkova-Kostova AT. Cuadrado A, et al. Nat Rev Drug Discov. 2019 Apr;18(4):295-317. doi: 10.1038/s41573-018-0008-x. Nat Rev Drug Discov. 2019. PMID: 30610225 Review.
NFE2-Related Transcription Factor 2 Coordinates Antioxidant Defense with Thyroglobulin Production and Iodination in the Thyroid Gland.
Ziros PG, Habeos IG, Chartoumpekis DV, Ntalampyra E, Somm E, Renaud CO, Bongiovanni M, Trougakos IP, Yamamoto M, Kensler TW, Santisteban P, Carrasco N, Ris-Stalpers C, Amendola E, Liao XH, Rossich L, Thomasz L, Juvenal GJ, Refetoff S, Sykiotis GP. Ziros PG, et al. Thyroid. 2018 Jun;28(6):780-798. doi: 10.1089/thy.2018.0018. Thyroid. 2018. PMID: 29742982 Free PMC article.
Disruption of nuclear factor (erythroid-derived-2)-like 2 antioxidant signaling: a mechanism for impaired activation of stem cells and delayed regeneration of skeletal muscle.
Shelar SB, Narasimhan M, Shanmugam G, Litovsky SH, Gounder SS, Karan G, Arulvasu C, Kensler TW, Hoidal JR, Darley-Usmar VM, Rajasekaran NS. Shelar SB, et al. FASEB J. 2016 May;30(5):1865-79. doi: 10.1096/fj.201500153. Epub 2016 Feb 2. FASEB J. 2016. PMID: 26839378 Free PMC article.
., Kensler, T. W., Hoidal, J. R., Darley-Usmar, V. M., Rajasekaran, N. S. Disruption of nuclear factor (erythroid-derived-2)-like 2 antioxidant signaling: a mechanism for impaired activation of stem cells and delayed regeneration of skeletal muscle....
., Kensler, T. W., Hoidal, J. R., Darley-Usmar, V. M., Rajasekaran, N. S. Disruption of nuclear factor (erythroid-derived-2)-l …
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