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Development of resistance mechanisms to the growth-inhibitory effects of transforming growth factor-beta during tumor progression.
Filmus J, Kerbel RS. Filmus J, et al. Among authors: kerbel rs. Curr Opin Oncol. 1993 Jan;5(1):123-9. Curr Opin Oncol. 1993. PMID: 8427884 Review.
Lineage-specific mechanism of drug and radiation resistance in melanoma mediated by tyrosinase-related protein 2.
Pak BJ, Chu W, Lu SJ, Kerbel RS, Ben-David Y. Pak BJ, et al. Among authors: kerbel rs. Cancer Metastasis Rev. 2001;20(1-2):27-32. doi: 10.1023/a:1013175516793. Cancer Metastasis Rev. 2001. PMID: 11831643 Review.
Induction of anoikis and suppression of human ovarian tumor growth in vivo by down-regulation of Bcl-X(L).
Frankel A, Rosen K, Filmus J, Kerbel RS. Frankel A, et al. Among authors: kerbel rs. Cancer Res. 2001 Jun 15;61(12):4837-41. Cancer Res. 2001. PMID: 11406560
'Accidental' anti-angiogenic drugs. anti-oncogene directed signal transduction inhibitors and conventional chemotherapeutic agents as examples.
Kerbel RS, Viloria-Petit A, Klement G, Rak J. Kerbel RS, et al. Eur J Cancer. 2000 Jun;36(10):1248-57. doi: 10.1016/s0959-8049(00)00092-7. Eur J Cancer. 2000. PMID: 10882863 Review.
Activated Ras prevents downregulation of Bcl-X(L) triggered by detachment from the extracellular matrix. A mechanism of Ras-induced resistance to anoikis in intestinal epithelial cells.
Rosen K, Rak J, Leung T, Dean NM, Kerbel RS, Filmus J. Rosen K, et al. Among authors: kerbel rs. J Cell Biol. 2000 Apr 17;149(2):447-56. doi: 10.1083/jcb.149.2.447. J Cell Biol. 2000. PMID: 10769035 Free PMC article.
What is the optimal rodent model for anti-tumor drug testing?
Kerbel RS. Kerbel RS. Cancer Metastasis Rev. 1998-1999;17(3):301-4. doi: 10.1023/a:1006152915959. Cancer Metastasis Rev. 1998. PMID: 10352884 Review.
Normoxic and hypoxic regulation of vascular endothelial growth factor (VEGF) by astrocytoma cells is mediated by Ras.
Feldkamp MM, Lau N, Rak J, Kerbel RS, Guha A. Feldkamp MM, et al. Among authors: kerbel rs. Int J Cancer. 1999 Mar 31;81(1):118-24. doi: 10.1002/(sici)1097-0215(19990331)81:1<118::aid-ijc20>3.0.co;2-5. Int J Cancer. 1999. PMID: 10077162
Downregulation of the pro-apoptotic protein Bak is required for the ras-induced transformation of intestinal epithelial cells.
Rosen K, Rak J, Jin J, Kerbel RS, Newman MJ, Filmus J. Rosen K, et al. Among authors: kerbel rs. Curr Biol. 1998 Dec 3;8(24):1331-4. doi: 10.1016/s0960-9822(07)00564-7. Curr Biol. 1998. PMID: 9843689
Reversal of intrinsic and acquired forms of drug resistance by hyaluronidase treatment of solid tumors.
St Croix B, Man S, Kerbel RS. St Croix B, et al. Among authors: kerbel rs. Cancer Lett. 1998 Sep 11;131(1):35-44. doi: 10.1016/s0304-3835(98)00199-2. Cancer Lett. 1998. PMID: 9839618 Review.
Kerbel, Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents, BioEssays 13 (1991) 31-36; R.S. Kerbel, A cancer therapy resistant to resistance, Nature 390 (1997) 335-336). Another is to devise methods whi
Kerbel, Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents, BioEssays
New targets, drugs, and approaches for the treatment of cancer: an overview.
Kerbel RS. Kerbel RS. Cancer Metastasis Rev. 1998 Jun;17(2):145-7. doi: 10.1023/a:1006040928755. Cancer Metastasis Rev. 1998. PMID: 9770109 No abstract available.
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