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Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis.
Valdes AM, Spector TD, Tamm A, Kisand K, Doherty SA, Dennison EM, Mangino M, Tamm A, Kerna I, Hart DJ, Wheeler M, Cooper C, Lories RJ, Arden NK, Doherty M. Valdes AM, et al. Among authors: kerna i. Arthritis Rheum. 2010 Aug;62(8):2347-52. doi: 10.1002/art.27530. Arthritis Rheum. 2010. PMID: 20506137 Free article.
Large scale replication study of the association between HLA class II/BTNL2 variants and osteoarthritis of the knee in European-descent populations.
Valdes AM, Styrkarsdottir U, Doherty M, Morris DL, Mangino M, Tamm A, Doherty SA, Kisand K, Kerna I, Tamm A, Wheeler M, Maciewicz RA, Zhang W, Muir KR, Dennison EM, Hart DJ, Metrustry S, Jonsdottir I, Jonsson GF, Jonsson H, Ingvarsson T, Cooper C, Vyse TJ, Spector TD, Stefansson K, Arden NK. Valdes AM, et al. Among authors: kerna i. PLoS One. 2011;6(8):e23371. doi: 10.1371/journal.pone.0023371. Epub 2011 Aug 10. PLoS One. 2011. PMID: 21853121 Free PMC article.
A meta-analysis of interleukin-6 promoter polymorphisms on risk of hip and knee osteoarthritis.
Valdes AM, Arden NK, Tamm A, Kisand K, Doherty S, Pola E, Cooper C, Tamm A, Muir KR, Kerna I, Hart D, O'Neil F, Zhang W, Spector TD, Maciewicz RA, Doherty M. Valdes AM, et al. Among authors: kerna i. Osteoarthritis Cartilage. 2010 May;18(5):699-704. doi: 10.1016/j.joca.2009.12.012. Epub 2010 Feb 6. Osteoarthritis Cartilage. 2010. PMID: 20175976 Free article.
The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance.
Valdes AM, Evangelou E, Kerkhof HJ, Tamm A, Doherty SA, Kisand K, Tamm A, Kerna I, Uitterlinden A, Hofman A, Rivadeneira F, Cooper C, Dennison EM, Zhang W, Muir KR, Ioannidis JP, Wheeler M, Maciewicz RA, van Meurs JB, Arden NK, Spector TD, Doherty M. Valdes AM, et al. Among authors: kerna i. Ann Rheum Dis. 2011 May;70(5):873-5. doi: 10.1136/ard.2010.134155. Epub 2010 Sep 24. Ann Rheum Dis. 2011. PMID: 20870806 Free PMC article. No abstract available.
Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis.
Kerkhof HJ, Doherty M, Arden NK, Abramson SB, Attur M, Bos SD, Cooper C, Dennison EM, Doherty SA, Evangelou E, Hart DJ, Hofman A, Javaid K, Kerna I, Kisand K, Kloppenburg M, Krasnokutsky S, Maciewicz RA, Meulenbelt I, Muir KR, Rivadeneira F, Samuels J, Sezgin M, Slagboom E, Smith AJ, Spector TD, Tamm A, Tamm A, Uitterlinden AG, Wheeler M, Zhai G, Zhang W, van Meurs JB, Valdes AM. Kerkhof HJ, et al. Among authors: kerna i. Osteoarthritis Cartilage. 2011 Mar;19(3):265-71. doi: 10.1016/j.joca.2010.12.003. Epub 2010 Dec 10. Osteoarthritis Cartilage. 2011. PMID: 21146623 Free article. Review.
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