Kerr ID - Search Results

1

Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3.

Subramanian S, Hardt M, Choe Y, Niles RK, Johansen EB, Legac J, Gut J, Kerr ID, Craik CS, Rosenthal PJ. Subramanian S, et al. Among authors: kerr id. PLoS One. 2009;4(4):e5156. doi: 10.1371/journal.pone.0005156. Epub 2009 Apr 9. PLoS One. 2009. PMID: 19357776 Free PMC article.

2

Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity.

Kerr ID, Lee JH, Pandey KC, Harrison A, Sajid M, Rosenthal PJ, Brinen LS. Kerr ID, et al. J Med Chem. 2009 Feb 12;52(3):852-7. doi: 10.1021/jm8013663. J Med Chem. 2009. PMID: 19128015 Free PMC article.

3

Vinyl sulfones as antiparasitic agents and a structural basis for drug design.

Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC, Caffrey CR, Legac J, Hansell E, McKerrow JH, Craik CS, Rosenthal PJ, Brinen LS. Kerr ID, et al. J Biol Chem. 2009 Sep 18;284(38):25697-703. doi: 10.1074/jbc.M109.014340. Epub 2009 Jul 20. J Biol Chem. 2009. PMID: 19620707 Free PMC article.

4

A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target.

He C, Nora GP, Schneider EL, Kerr ID, Hansell E, Hirata K, Gonzalez D, Sajid M, Boyd SE, Hruz P, Cobo ER, Le C, Liu WT, Eckmann L, Dorrestein PC, Houpt ER, Brinen LS, Craik CS, Roush WR, McKerrow J, Reed SL. He C, et al. Among authors: kerr id. J Biol Chem. 2010 Jun 11;285(24):18516-27. doi: 10.1074/jbc.M109.086181. Epub 2010 Apr 8. J Biol Chem. 2010. PMID: 20378535 Free PMC article.

5

Two approaches to discovering and developing new drugs for Chagas disease.

McKerrow JH, Doyle PS, Engel JC, Podust LM, Robertson SA, Ferreira R, Saxton T, Arkin M, Kerr ID, Brinen LS, Craik CS. McKerrow JH, et al. Among authors: kerr id. Mem Inst Oswaldo Cruz. 2009 Jul;104 Suppl 1(0 1):263-9. doi: 10.1590/s0074-02762009000900034. Mem Inst Oswaldo Cruz. 2009. PMID: 19753483 Free PMC article.

6

Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei.

Kerr ID, Wu P, Marion-Tsukamaki R, Mackey ZB, Brinen LS. Kerr ID, et al. PLoS Negl Trop Dis. 2010 Jun 8;4(6):e701. doi: 10.1371/journal.pntd.0000701. PLoS Negl Trop Dis. 2010. PMID: 20544024 Free PMC article.

7

Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases.

Bryant C, Kerr ID, Debnath M, Ang KK, Ratnam J, Ferreira RS, Jaishankar P, Zhao D, Arkin MR, McKerrow JH, Brinen LS, Renslo AR. Bryant C, et al. Among authors: kerr id. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6218-21. doi: 10.1016/j.bmcl.2009.08.098. Epub 2009 Sep 3. Bioorg Med Chem Lett. 2009. PMID: 19773167 Free PMC article.

8

In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.

Chen YT, Brinen LS, Kerr ID, Hansell E, Doyle PS, McKerrow JH, Roush WR. Chen YT, et al. Among authors: kerr id. PLoS Negl Trop Dis. 2010 Sep 14;4(9):e825. doi: 10.1371/journal.pntd.0000825. PLoS Negl Trop Dis. 2010. PMID: 20856868 Free PMC article.

9

Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy.

Brak K, Kerr ID, Barrett KT, Fuchi N, Debnath M, Ang K, Engel JC, McKerrow JH, Doyle PS, Brinen LS, Ellman JA. Brak K, et al. Among authors: kerr id. J Med Chem. 2010 Feb 25;53(4):1763-73. doi: 10.1021/jm901633v. J Med Chem. 2010. PMID: 20088534 Free PMC article.

10

Structural studies of pterin-based inhibitors of dihydropteroate synthase.

Hevener KE, Yun MK, Qi J, Kerr ID, Babaoglu K, Hurdle JG, Balakrishna K, White SW, Lee RE. Hevener KE, et al. Among authors: kerr id. J Med Chem. 2010 Jan 14;53(1):166-77. doi: 10.1021/jm900861d. J Med Chem. 2010. PMID: 19899766 Free PMC article.

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