Cigarette smoke modifies and inactivates SPLUNC1, leading to airway dehydration.
Moore PJ, Reidel B, Ghosh A, Sesma J, Kesimer M, Tarran R.
Moore PJ, et al. Among authors: kesimer m.
FASEB J. 2018 Jun 11;32(12):fj201800345R. doi: 10.1096/fj.201800345R. Online ahead of print.
FASEB J. 2018.
PMID: 29890087
Free PMC article.
These findings suggest that the CS-induced defects in SPLUNC1 can be circumvented, thus making SPX-101 a novel candidate for the treatment of mucus dehydration in COPD. -Moore, P. J., Reidel, B., Ghosh, A., Sesma, J., Kesimer, M., Tarran, R. Cigarette smoke modifies …
These findings suggest that the CS-induced defects in SPLUNC1 can be circumvented, thus making SPX-101 a novel candidate for the treatment o …