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Role of melanocortinergic neurons in feeding and the agouti obesity syndrome.
Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD. Fan W, et al. Nature. 1997 Jan 9;385(6612):165-8. doi: 10.1038/385165a0. Nature. 1997. PMID: 8990120
A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse.
Butler AA, Kesterson RA, Khong K, Cullen MJ, Pelleymounter MA, Dekoning J, Baetscher M, Cone RD. Butler AA, et al. Endocrinology. 2000 Sep;141(9):3518-21. doi: 10.1210/endo.141.9.7791. Endocrinology. 2000. PMID: 10965927
Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2.
Coste SC, Kesterson RA, Heldwein KA, Stevens SL, Heard AD, Hollis JH, Murray SE, Hill JK, Pantely GA, Hohimer AR, Hatton DC, Phillips TJ, Finn DA, Low MJ, Rittenberg MB, Stenzel P, Stenzel-Poore MP. Coste SC, et al. Nat Genet. 2000 Apr;24(4):403-9. doi: 10.1038/74255. Nat Genet. 2000. PMID: 10742107
The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation.
Cone RD, Lu D, Koppula S, Vage DI, Klungland H, Boston B, Chen W, Orth DN, Pouton C, Kesterson RA. Cone RD, et al. Recent Prog Horm Res. 1996;51:287-317; discussion 318. Recent Prog Horm Res. 1996. PMID: 8701084 Review.
Targeted disruption of the melanocortin-4 receptor results in obesity in mice.
Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F. Huszar D, et al. Cell. 1997 Jan 10;88(1):131-41. doi: 10.1016/s0092-8674(00)81865-6. Cell. 1997. PMID: 9019399
Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors.
Hruby VJ, Lu D, Sharma SD, Castrucci AL, Kesterson RA, al-Obeidi FA, Hadley ME, Cone RD. Hruby VJ, et al. J Med Chem. 1995 Sep 1;38(18):3454-61. doi: 10.1021/jm00018a005. J Med Chem. 1995. PMID: 7658432
Melanocortin antagonists define two distinct pathways of cardiovascular control by alpha- and gamma-melanocyte-stimulating hormones.
Li SJ, Varga K, Archer P, Hruby VJ, Sharma SD, Kesterson RA, Cone RD, Kunos G. Li SJ, et al. J Neurosci. 1996 Aug 15;16(16):5182-8. doi: 10.1523/JNEUROSCI.16-16-05182.1996. J Neurosci. 1996. PMID: 8756446 Free PMC article.
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