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Global analysis of fungal morphology exposes mechanisms of host cell escape.
O'Meara TR, Veri AO, Ketela T, Jiang B, Roemer T, Cowen LE. O'Meara TR, et al. Nat Commun. 2015 Mar 31;6:6741. doi: 10.1038/ncomms7741. Nat Commun. 2015. PMID: 25824284 Free PMC article.
Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans.
Xu D, Jiang B, Ketela T, Lemieux S, Veillette K, Martel N, Davison J, Sillaots S, Trosok S, Bachewich C, Bussey H, Youngman P, Roemer T. Xu D, et al. PLoS Pathog. 2007 Jun;3(6):e92. doi: 10.1371/journal.ppat.0030092. PLoS Pathog. 2007. PMID: 17604452 Free PMC article.
Functional Genomic Analysis of Candida albicans Adherence Reveals a Key Role for the Arp2/3 Complex in Cell Wall Remodelling and Biofilm Formation.
Lee JA, Robbins N, Xie JL, Ketela T, Cowen LE. Lee JA, et al. PLoS Genet. 2016 Nov 21;12(11):e1006452. doi: 10.1371/journal.pgen.1006452. eCollection 2016 Nov. PLoS Genet. 2016. PMID: 27870871 Free PMC article.
The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation.
Xie JL, Qin L, Miao Z, Grys BT, Diaz JC, Ting K, Krieger JR, Tong J, Tan K, Leach MD, Ketela T, Moran MF, Krysan DJ, Boone C, Andrews BJ, Selmecki A, Ho Wong K, Robbins N, Cowen LE. Xie JL, et al. Nat Commun. 2017 Sep 11;8(1):499. doi: 10.1038/s41467-017-00547-y. Nat Commun. 2017. PMID: 28894103 Free PMC article.
Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery.
Roemer T, Jiang B, Davison J, Ketela T, Veillette K, Breton A, Tandia F, Linteau A, Sillaots S, Marta C, Martel N, Veronneau S, Lemieux S, Kauffman S, Becker J, Storms R, Boone C, Bussey H. Roemer T, et al. Mol Microbiol. 2003 Oct;50(1):167-81. doi: 10.1046/j.1365-2958.2003.03697.x. Mol Microbiol. 2003. PMID: 14507372
A genome wide shRNA screen identifies α/β hydrolase domain containing 4 (ABHD4) as a novel regulator of anoikis resistance.
Simpson CD, Hurren R, Kasimer D, MacLean N, Eberhard Y, Ketela T, Moffat J, Schimmer AD. Simpson CD, et al. Apoptosis. 2012 Jul;17(7):666-78. doi: 10.1007/s10495-012-0723-4. Apoptosis. 2012. PMID: 22488300
A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.
Vizeacoumar FJ, Arnold R, Vizeacoumar FS, Chandrashekhar M, Buzina A, Young JT, Kwan JH, Sayad A, Mero P, Lawo S, Tanaka H, Brown KR, Baryshnikova A, Mak AB, Fedyshyn Y, Wang Y, Brito GC, Kasimer D, Makhnevych T, Ketela T, Datti A, Babu M, Emili A, Pelletier L, Wrana J, Wainberg Z, Kim PM, Rottapel R, O'Brien CA, Andrews B, Boone C, Moffat J. Vizeacoumar FJ, et al. Mol Syst Biol. 2013 Oct 8;9:696. doi: 10.1038/msb.2013.54. Mol Syst Biol. 2013. PMID: 24104479 Free PMC article.
Differential regulation of FGFR3 by PTPN1 and PTPN2.
St-Germain JR, Taylor P, Zhang W, Li Z, Ketela T, Moffat J, Neel BG, Trudel S, Moran MF. St-Germain JR, et al. Proteomics. 2015 Jan;15(2-3):419-33. doi: 10.1002/pmic.201400259. Epub 2014 Dec 17. Proteomics. 2015. PMID: 25311528 Free PMC article.
Cytokinetic effects of Wee1 disruption in pancreatic cancer.
Chang Q, Chandrashekhar M, Ketela T, Fedyshyn Y, Moffat J, Hedley D. Chang Q, et al. Cell Cycle. 2016;15(4):593-604. doi: 10.1080/15384101.2016.1138188. Cell Cycle. 2016. PMID: 26890070 Free PMC article.
The SAGA Deubiquitination Module Promotes DNA Repair and Class Switch Recombination through ATM and DNAPK-Mediated γH2AX Formation.
Ramachandran S, Haddad D, Li C, Le MX, Ling AK, So CC, Nepal RM, Gommerman JL, Yu K, Ketela T, Moffat J, Martin A. Ramachandran S, et al. Cell Rep. 2016 May 17;15(7):1554-1565. doi: 10.1016/j.celrep.2016.04.041. Epub 2016 May 5. Cell Rep. 2016. PMID: 27160905 Free PMC article.
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