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2-thioxanthines are mechanism-based inactivators of myeloperoxidase that block oxidative stress during inflammation.
Tidén AK, Sjögren T, Svensson M, Bernlind A, Senthilmohan R, Auchère F, Norman H, Markgren PO, Gustavsson S, Schmidt S, Lundquist S, Forbes LV, Magon NJ, Paton LN, Jameson GN, Eriksson H, Kettle AJ. Tidén AK, et al. Among authors: kettle aj. J Biol Chem. 2011 Oct 28;286(43):37578-89. doi: 10.1074/jbc.M111.266981. Epub 2011 Aug 31. J Biol Chem. 2011. PMID: 21880720 Free PMC article.
Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations.
Koelsch M, Mallak R, Graham GG, Kajer T, Milligan MK, Nguyen LQ, Newsham DW, Keh JS, Kettle AJ, Scott KF, Ziegler JB, Pattison DI, Fu S, Hawkins CL, Rees MD, Davies MJ. Koelsch M, et al. Among authors: kettle aj. Biochem Pharmacol. 2010 Apr 15;79(8):1156-64. doi: 10.1016/j.bcp.2009.11.024. Epub 2009 Dec 5. Biochem Pharmacol. 2010. PMID: 19968966
Inactivation of human myeloperoxidase by hydrogen peroxide.
Paumann-Page M, Furtmüller PG, Hofbauer S, Paton LN, Obinger C, Kettle AJ. Paumann-Page M, et al. Among authors: kettle aj. Arch Biochem Biophys. 2013 Nov 1;539(1):51-62. doi: 10.1016/j.abb.2013.09.004. Epub 2013 Sep 11. Arch Biochem Biophys. 2013. PMID: 24035742 Free PMC article.
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