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Pyrazolo[1,5a]pyrimidines as a new class of FUSE binding protein 1 (FUBP1) inhibitors.
Bioorg Med Chem. 2016 Nov 15;24(22):5717-5729. doi: 10.1016/j.bmc.2016.09.015. Epub 2016 Sep 14.
Bioorg Med Chem. 2016.
PMID: 27729195
Camptothecin and its analog SN-38, the active metabolite of irinotecan, inhibit binding of the transcriptional regulator and oncoprotein FUBP1 to its DNA target sequence FUSE.
Khageh Hosseini S, Kolterer S, Steiner M, von Manstein V, Gerlach K, Trojan J, Waidmann O, Zeuzem S, Schulze JO, Hahn S, Steinhilber D, Gatterdam V, Tampé R, Biondi RM, Proschak E, Zörnig M.
Khageh Hosseini S, et al.
Biochem Pharmacol. 2017 Dec 15;146:53-62. doi: 10.1016/j.bcp.2017.10.003. Epub 2017 Oct 13.
Biochem Pharmacol. 2017.
PMID: 29031818
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