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MITF: master regulator of melanocyte development and melanoma oncogene.
Levy C, Khaled M, Fisher DE. Levy C, et al. Among authors: khaled m. Trends Mol Med. 2006 Sep;12(9):406-14. doi: 10.1016/j.molmed.2006.07.008. Epub 2006 Aug 8. Trends Mol Med. 2006. PMID: 16899407 Review.
Interactions of Melanoma Cells with Distal Keratinocytes Trigger Metastasis via Notch Signaling Inhibition of MITF.
Golan T, Messer AR, Amitai-Lange A, Melamed Z, Ohana R, Bell RE, Kapitansky O, Lerman G, Greenberger S, Khaled M, Amar N, Albrengues J, Gaggioli C, Gonen P, Tabach Y, Sprinzak D, Shalom-Feuerstein R, Levy C. Golan T, et al. Among authors: khaled m. Mol Cell. 2015 Aug 20;59(4):664-76. doi: 10.1016/j.molcel.2015.06.028. Epub 2015 Jul 30. Mol Cell. 2015. PMID: 26236014
Transcription factor/microRNA axis blocks melanoma invasion program by miR-211 targeting NUAK1.
Bell RE, Khaled M, Netanely D, Schubert S, Golan T, Buxbaum A, Janas MM, Postolsky B, Goldberg MS, Shamir R, Levy C. Bell RE, et al. Among authors: khaled m. J Invest Dermatol. 2014 Feb;134(2):441-451. doi: 10.1038/jid.2013.340. Epub 2013 Aug 9. J Invest Dermatol. 2014. PMID: 23934065
Feed-forward microprocessing and splicing activities at a microRNA-containing intron.
Janas MM, Khaled M, Schubert S, Bernstein JG, Golan D, Veguilla RA, Fisher DE, Shomron N, Levy C, Novina CD. Janas MM, et al. Among authors: khaled m. PLoS Genet. 2011 Oct;7(10):e1002330. doi: 10.1371/journal.pgen.1002330. Epub 2011 Oct 20. PLoS Genet. 2011. PMID: 22028668 Free PMC article.
Hypoxia-induced transcriptional repression of the melanoma-associated oncogene MITF.
Feige E, Yokoyama S, Levy C, Khaled M, Igras V, Lin RJ, Lee S, Widlund HR, Granter SR, Kung AL, Fisher DE. Feige E, et al. Among authors: khaled m. Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):E924-33. doi: 10.1073/pnas.1106351108. Epub 2011 Sep 26. Proc Natl Acad Sci U S A. 2011. PMID: 21949374 Free PMC article.
Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma.
Levy C, Khaled M, Iliopoulos D, Janas MM, Schubert S, Pinner S, Chen PH, Li S, Fletcher AL, Yokoyama S, Scott KL, Garraway LA, Song JS, Granter SR, Turley SJ, Fisher DE, Novina CD. Levy C, et al. Among authors: khaled m. Mol Cell. 2010 Dec 10;40(5):841-9. doi: 10.1016/j.molcel.2010.11.020. Epub 2010 Nov 25. Mol Cell. 2010. PMID: 21109473 Free PMC article.
Control of melanocyte differentiation by a MITF-PDE4D3 homeostatic circuit.
Khaled M, Levy C, Fisher DE. Khaled M, et al. Genes Dev. 2010 Oct 15;24(20):2276-81. doi: 10.1101/gad.1937710. Genes Dev. 2010. PMID: 20952536 Free PMC article.
Lineage-specific transcriptional regulation of DICER by MITF in melanocytes.
Levy C, Khaled M, Robinson KC, Veguilla RA, Chen PH, Yokoyama S, Makino E, Lu J, Larue L, Beermann F, Chin L, Bosenberg M, Song JS, Fisher DE. Levy C, et al. Among authors: khaled m. Cell. 2010 Jun 11;141(6):994-1005. doi: 10.1016/j.cell.2010.05.004. Cell. 2010. PMID: 20550935 Free PMC article.
Pharmacologic suppression of MITF expression via HDAC inhibitors in the melanocyte lineage.
Yokoyama S, Feige E, Poling LL, Levy C, Widlund HR, Khaled M, Kung AL, Fisher DE. Yokoyama S, et al. Among authors: khaled m. Pigment Cell Melanoma Res. 2008 Aug;21(4):457-63. doi: 10.1111/j.1755-148X.2008.00480.x. Epub 2008 Jun 27. Pigment Cell Melanoma Res. 2008. PMID: 18627530 Free PMC article.
OCT4 impedes cell fate redirection by the melanocyte lineage master regulator MITF in mouse ESCs.
Sheinboim D, Maza I, Dror I, Parikh S, Krupalnik V, Bell RE, Zviran A, Suita Y, Hakim O, Mandel-Gutfreund Y, Khaled M, Hanna JH, Levy C. Sheinboim D, et al. Among authors: khaled m. Nat Commun. 2017 Oct 18;8(1):1022. doi: 10.1038/s41467-017-01122-1. Nat Commun. 2017. PMID: 29044103 Free PMC article.
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