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Clinical improvement in psoriasis with specific targeting of interleukin-23.
Kopp T, Riedl E, Bangert C, Bowman EP, Greisenegger E, Horowitz A, Kittler H, Blumenschein WM, McClanahan TK, Marbury T, Zachariae C, Xu D, Hou XS, Mehta A, Zandvliet AS, Montgomery D, van Aarle F, Khalilieh S. Kopp T, et al. Among authors: khalilieh s. Nature. 2015 May 14;521(7551):222-6. doi: 10.1038/nature14175. Epub 2015 Mar 9. Nature. 2015. PMID: 25754330 Clinical Trial.
Effect of tildrakizumab (MK-3222), a high affinity, selective anti-IL23p19 monoclonal antibody, on cytochrome P450 metabolism in subjects with moderate to severe psoriasis.
Khalilieh S, Hussain A, Montgomery D, Levine V, Shaw PM, Bodrug I, Mekokishvili L, Bailey-Smith C, Glasgow XS, Cheng A, Martinho M, Iwamoto M. Khalilieh S, et al. Br J Clin Pharmacol. 2018 Oct;84(10):2292-2302. doi: 10.1111/bcp.13670. Epub 2018 Jul 31. Br J Clin Pharmacol. 2018. PMID: 29926968 Free PMC article. Clinical Trial.
Moderate Hepatic Impairment Does Not Affect Doravirine Pharmacokinetics.
Khalilieh S, Yee KL, Liu R, Fan L, Sanchez RI, Auger P, Triantafyllou I, Stypinski D, Lasseter KC, Marbury T, Iwamoto M. Khalilieh S, et al. J Clin Pharmacol. 2017 Jun;57(6):777-783. doi: 10.1002/jcph.857. Epub 2016 Dec 27. J Clin Pharmacol. 2017. PMID: 28026013 Clinical Trial.
Severe Renal Impairment Has Minimal Impact on Doravirine Pharmacokinetics.
Ankrom W, Yee KL, Sanchez RI, Adedoyin A, Fan L, Marbury T, Preston RA, Iwamoto M, Khalilieh SG. Ankrom W, et al. Antimicrob Agents Chemother. 2018 Jul 27;62(8):e00326-18. doi: 10.1128/AAC.00326-18. Print 2018 Aug. Antimicrob Agents Chemother. 2018. PMID: 29891610 Free PMC article. Clinical Trial.
44 results