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Chirality of TLR-2 ligand Pam3CysSK4 in fully synthetic peptide conjugates critically influences the induction of specific CD8+ T-cells.
Khan S, Weterings JJ, Britten CM, de Jong AR, Graafland D, Melief CJ, van der Burg SH, van der Marel G, Overkleeft HS, Filippov DV, Ossendorp F. Khan S, et al. Mol Immunol. 2009 Mar;46(6):1084-91. doi: 10.1016/j.molimm.2008.10.006. Epub 2008 Nov 22. Mol Immunol. 2009. PMID: 19027958
We have recently explored the cellular mechanisms underlying the efficient induction of a CD8(+) cytotoxic T lymphocyte response by such synthetic model vaccines [Khan, S., Bijker, M.S., Weterings, J.J., Tanke, H.J., Adema, G.J., van, H.T., Drijfhout, J.W., M …
We have recently explored the cellular mechanisms underlying the efficient induction of a CD8(+) cytotoxic T lymphocyte response by such syn …
Synthesis of 2-alkoxy-8-hydroxyadenylpeptides: towards synthetic epitope-based vaccines.
Weterings JJ, Khan S, van der Heden GJ, Drijfhout JW, Melief CJ, Overkleeft HS, van der Burg SH, Ossendorp F, van der Marel GA, Filippov DV. Weterings JJ, et al. Among authors: khan s. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3258-61. doi: 10.1016/j.bmcl.2006.03.034. Epub 2006 Apr 11. Bioorg Med Chem Lett. 2006. PMID: 16581248
Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells.
Khan S, Bijker MS, Weterings JJ, Tanke HJ, Adema GJ, van Hall T, Drijfhout JW, Melief CJ, Overkleeft HS, van der Marel GA, Filippov DV, van der Burg SH, Ossendorp F. Khan S, et al. J Biol Chem. 2007 Jul 20;282(29):21145-59. doi: 10.1074/jbc.M701705200. Epub 2007 Apr 26. J Biol Chem. 2007. PMID: 17462991 Free article.
Antigen storage compartments in mature dendritic cells facilitate prolonged cytotoxic T lymphocyte cross-priming capacity.
van Montfoort N, Camps MG, Khan S, Filippov DV, Weterings JJ, Griffith JM, Geuze HJ, van Hall T, Verbeek JS, Melief CJ, Ossendorp F. van Montfoort N, et al. Among authors: khan s. Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6730-5. doi: 10.1073/pnas.0900969106. Epub 2009 Apr 3. Proc Natl Acad Sci U S A. 2009. PMID: 19346487 Free PMC article.
Synthesis of modified and hybrid protein derived biopolymers.
Weterings JJ, Khan S, Drijfhout JW, Ossendorp F, Overkleeft HS, van der Marel GA, Filippov DV. Weterings JJ, et al. Among authors: khan s. Adv Exp Med Biol. 2009;611:141-2. doi: 10.1007/978-0-387-73657-0_63. Adv Exp Med Biol. 2009. PMID: 19400130 No abstract available.
Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes.
Kessler JH, Khan S, Seifert U, Le Gall S, Chow KM, Paschen A, Bres-Vloemans SA, de Ru A, van Montfoort N, Franken KL, Benckhuijsen WE, Brooks JM, van Hall T, Ray K, Mulder A, Doxiadis II, van Swieten PF, Overkleeft HS, Prat A, Tomkinson B, Neefjes J, Kloetzel PM, Rodgers DW, Hersh LB, Drijfhout JW, van Veelen PA, Ossendorp F, Melief CJ. Kessler JH, et al. Among authors: khan s. Nat Immunol. 2011 Jan;12(1):45-53. doi: 10.1038/ni.1974. Epub 2010 Dec 12. Nat Immunol. 2011. PMID: 21151101
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