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The effect of alginate oligosaccharides on the mechanical properties of Gram-negative biofilms.
Powell LC, Sowedan A, Khan S, Wright CJ, Hawkins K, Onsøyen E, Myrvold R, Hill KE, Thomas DW. Powell LC, et al. Among authors: Khan S. Biofouling. 2013;29(4):413-21. doi: 10.1080/08927014.2013.777954. Biofouling. 2013. PMID: 23574333
AFM demonstrated structural alterations in the biofilms exposed to OligoG, with significantly lower Young's moduli than the untreated biofilms, (149 MPa vs 242 MPa; p < 0.05), a decreased resistance to hydrodynamic shear and an increased surface irregularity (Ra) in the untreated controls (35.2 nm ± 7.6 vs 12.1 nm ± 5.4; p < 0.05). ...
AFM demonstrated structural alterations in the biofilms exposed to OligoG, with significantly lower Young's moduli than the untreated …
Alginate Oligosaccharide-Induced Modification of the lasI-lasR and rhlI-rhlR Quorum-Sensing Systems in Pseudomonas aeruginosa.
Jack AA, Khan S, Powell LC, Pritchard MF, Beck K, Sadh H, Sutton L, Cavaliere A, Florance H, Rye PD, Thomas DW, Hill KE. Jack AA, et al. Among authors: Khan S. Antimicrob Agents Chemother. 2018 Apr 26;62(5):e02318-17. doi: 10.1128/AAC.02318-17. Print 2018 May. Antimicrob Agents Chemother. 2018. PMID: 29463534 Free PMC article.
The antimicrobial effects of the alginate oligomer OligoG CF-5/20 are independent of direct bacterial cell membrane disruption.
Pritchard MF, Powell LC, Khan S, Griffiths PC, Mansour OT, Schweins R, Beck K, Buurma NJ, Dempsey CE, Wright CJ, Rye PD, Hill KE, Thomas DW, Ferguson EL. Pritchard MF, et al. Among authors: Khan S. Sci Rep. 2017 Mar 31;7:44731. doi: 10.1038/srep44731. Sci Rep. 2017. PMID: 28361894 Free PMC article.
Alginate oligosaccharides inhibit fungal cell growth and potentiate the activity of antifungals against Candida and Aspergillus spp.
Tøndervik A, Sletta H, Klinkenberg G, Emanuel C, Powell LC, Pritchard MF, Khan S, Craine KM, Onsøyen E, Rye PD, Wright C, Thomas DW, Hill KE. Tøndervik A, et al. Among authors: Khan S. PLoS One. 2014 Nov 19;9(11):e112518. doi: 10.1371/journal.pone.0112518. eCollection 2014. PLoS One. 2014. PMID: 25409186 Free PMC article.
Overcoming drug resistance with alginate oligosaccharides able to potentiate the action of selected antibiotics.
Khan S, Tøndervik A, Sletta H, Klinkenberg G, Emanuel C, Onsøyen E, Myrvold R, Howe RA, Walsh TR, Hill KE, Thomas DW. Khan S, et al. Antimicrob Agents Chemother. 2012 Oct;56(10):5134-41. doi: 10.1128/AAC.00525-12. Epub 2012 Jul 23. Antimicrob Agents Chemother. 2012. PMID: 22825116 Free PMC article.
An Integrative Adapt Therapy for common mental health symptoms and adaptive stress amongst Rohingya, Chin, and Kachin refugees living in Malaysia: A randomized controlled trial.
Tay AK, Mung HK, Miah MAA, Balasundaram S, Ventevogel P, Badrudduza M, Khan S, Morgan K, Rees S, Mohsin M, Silove D. Tay AK, et al. Among authors: Khan S. PLoS Med. 2020 Mar 31;17(3):e1003073. doi: 10.1371/journal.pmed.1003073. eCollection 2020 Mar. PLoS Med. 2020. PMID: 32231364
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