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Some bacterial parameters influencing the neutrophil oxidative burst response to Pseudomonas aeruginosa biofilms.
Jensen ET, Kharazmi A, Høiby N, Costerton JW. Jensen ET, et al. Among authors: kharazmi a. APMIS. 1992 Aug;100(8):727-33. APMIS. 1992. PMID: 1325804
Persistence of bacteria in spite of a normal host immune system and relevant antibiotic treatment is a key problem in many chronic infections, such as the bronchopulmonary P. aeruginosa infection in cystic fibrosis patients. ...We conclude that biofilm bacteria, alt …
Persistence of bacteria in spite of a normal host immune system and relevant antibiotic treatment is a key problem in many chr …
Nitrous oxide production in sputum from cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection.
Kolpen M, Kühl M, Bjarnsholt T, Moser C, Hansen CR, Liengaard L, Kharazmi A, Pressler T, Høiby N, Jensen PØ. Kolpen M, et al. Among authors: kharazmi a. PLoS One. 2014 Jan 17;9(1):e84353. doi: 10.1371/journal.pone.0084353. eCollection 2014. PLoS One. 2014. PMID: 24465406 Free PMC article.
We found a maximum median concentration of 41.8 µM N2O (range 1.4-157.9 µM N2O). The concentration of N2O in the sputum was higher below the oxygenated layers. ...Such ability for anaerobic growth may be a hitherto ignored key aspect of chronic P. aeruginosa infecti …
We found a maximum median concentration of 41.8 µM N2O (range 1.4-157.9 µM N2O). The concentration of N2O in the sputum was higher be …
Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis.
Kolpen M, Hansen CR, Bjarnsholt T, Moser C, Christensen LD, van Gennip M, Ciofu O, Mandsberg L, Kharazmi A, Döring G, Givskov M, Høiby N, Jensen PØ. Kolpen M, et al. Among authors: kharazmi a. Thorax. 2010 Jan;65(1):57-62. doi: 10.1136/thx.2009.114512. Epub 2009 Oct 21. Thorax. 2010. PMID: 19846469
Mucoid conversion of Pseudomonas aeruginosa by hydrogen peroxide: a mechanism for virulence activation in the cystic fibrosis lung.
Mathee K, Ciofu O, Sternberg C, Lindum PW, Campbell JIA, Jensen P, Johnsen AH, Givskov M, Ohman DE, Søren M, Høiby N, Kharazmi A. Mathee K, et al. Among authors: kharazmi a. Microbiology (Reading). 1999 Jun;145 ( Pt 6):1349-1357. doi: 10.1099/13500872-145-6-1349. Microbiology (Reading). 1999. PMID: 10411261
To mimic the inflammatory environment of the CF lung, P. aeruginosa PAO1, a typical non-mucoid strain, was grown in a biofilm. ...This suggests that mucoid conversion is a response to oxygen radical exposure and that this response is a mechanism of def …
To mimic the inflammatory environment of the CF lung, P. aeruginosa PAO1, a typical non-mucoid strain, was grown in a biofilm. …
Robbins device in biofilm research.
Kharazmi A, Giwercman B, Høiby N. Kharazmi A, et al. Methods Enzymol. 1999;310:207-15. doi: 10.1016/s0076-6879(99)10018-1. Methods Enzymol. 1999. PMID: 10547794 No abstract available.
The immune response to chronic Pseudomonas aeruginosa lung infection in cystic fibrosis patients is predominantly of the Th2 type.
Moser C, Kjaergaard S, Pressler T, Kharazmi A, Koch C, Høiby N. Moser C, et al. Among authors: kharazmi a. APMIS. 2000 May;108(5):329-35. doi: 10.1034/j.1600-0463.2000.d01-64.x. APMIS. 2000. PMID: 10937769
We speculated whether this immune response in CF is of the Th2 type and whether a change to a Th1 type immune response could improve the prognosis. ...The clinical implication is that a change to a Th1 type immune response might improve the prognosis i …
We speculated whether this immune response in CF is of the Th2 type and whether a change to a Th1 type immune response could i …
Pseudomonas aeruginosa exotoxin A primes human monocyte oxidative burst response in vitro.
Patzer J, Nielsen H, Kharazmi A. Patzer J, et al. Among authors: kharazmi a. Microb Pathog. 1989 Aug;7(2):147-52. doi: 10.1016/0882-4010(89)90033-8. Microb Pathog. 1989. PMID: 2512464
Exotoxin A alone caused a dose-dependent stimulation of monocyte chemiluminescence responses, whereas neutrophil responses were inconsistent. Preincubation of monocytes with exotoxin A primed the cells for a significantly higher oxidative burst respons …
Exotoxin A alone caused a dose-dependent stimulation of monocyte chemiluminescence responses, whereas neutrophil responses wer …
Interleukin 6 primes human neutrophil and monocyte oxidative burst response.
Kharazmi A, Nielsen H, Rechnitzer C, Bendtzen K. Kharazmi A, et al. Immunol Lett. 1989 May;21(2):177-84. doi: 10.1016/0165-2478(89)90056-4. Immunol Lett. 1989. PMID: 2548955
Interleukin 6 (IL-6), a 26-kDa inducible protein, is a cytokine with multiple biological activities. This paper reports on the regulatory role of rIL-6 on the function of human polymorphonuclear and mononuclear leukocytes, a property not described previously. …
Interleukin 6 (IL-6), a 26-kDa inducible protein, is a cytokine with multiple biological activities. This paper reports on the …
Effect of streptokinase on human neutrophil function in vitro and in patients with acute myocardial infarction.
Hansen PR, Kharazmi A. Hansen PR, et al. Among authors: kharazmi a. J Mol Cell Cardiol. 1994 Aug;26(8):1061-8. doi: 10.1006/jmcc.1994.1126. J Mol Cell Cardiol. 1994. PMID: 7799446
The PMN priming by SK+plasma showed considerable interindividual variation, and was not mediated by a direct action of plasmin on PMNs. In 10 patients with acute myocardial infarction treated with SK, a reduction in superoxide production by PMNs was observed immedia …
The PMN priming by SK+plasma showed considerable interindividual variation, and was not mediated by a direct action of plasmin on PMN …
N-acetylcysteine inhibits human neutrophil and monocyte chemotaxis and oxidative metabolism.
Kharazmi A, Nielsen H, Schiøtz PO. Kharazmi A, et al. Int J Immunopharmacol. 1988;10(1):39-46. doi: 10.1016/0192-0561(88)90148-8. Int J Immunopharmacol. 1988. PMID: 3366508
The studies on the effect of NAC on neutrophil and monocyte chemotaxis showed that NAC inhibited chemotaxis of both cell types in a concentration dependent manner. ...NAC exhibited a similar pattern of inhibition on monocyte chemiluminescence response. These finding …
The studies on the effect of NAC on neutrophil and monocyte chemotaxis showed that NAC inhibited chemotaxis of both cell types in a c …
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