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Visualizing the generation of memory CD4 T cells in the whole body.
Reinhardt RL, Khoruts A, Merica R, Zell T, Jenkins MK. Reinhardt RL, et al. Among authors: khoruts a. Nature. 2001 Mar 1;410(6824):101-5. doi: 10.1038/35065111. Nature. 2001. PMID: 11242050
Here we use immunohistology to enumerate individual naive CD4 T cells, specific for a model antigen, in the whole bodies of adult mice. ...If antigen was injected with the microbial product lipopolysaccharide, proliferation and migration were enhanced, and two populations …
Here we use immunohistology to enumerate individual naive CD4 T cells, specific for a model antigen, in the whole bodies of adult mic …
Neuroantigen-specific Th2 cells are inefficient suppressors of experimental autoimmune encephalomyelitis induced by effector Th1 cells.
Khoruts A, Miller SD, Jenkins MK. Khoruts A, et al. J Immunol. 1995 Nov 15;155(10):5011-7. J Immunol. 1995. PMID: 7594508
We have identified a method of polarizing polyclonal populations of activated T helper cells toward either the Th1 or Th2 phenotype using different short-term in vitro culture conditions. ...
We have identified a method of polarizing polyclonal populations of activated T helper cells toward either the Th1 or Th2 phenotype u …
Studying immunological tolerance by physically monitoring antigen-specific T cells in vivo.
Khoruts A, Jenkins MK. Khoruts A, et al. Ann N Y Acad Sci. 1996 Feb 13;778:72-9. doi: 10.1111/j.1749-6632.1996.tb21116.x. Ann N Y Acad Sci. 1996. PMID: 8611018 Review. No abstract available.
The anatomy of T-cell activation and tolerance.
Mondino A, Khoruts A, Jenkins MK. Mondino A, et al. Among authors: khoruts a. Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2245-52. doi: 10.1073/pnas.93.6.2245. Proc Natl Acad Sci U S A. 1996. PMID: 8637857 Free PMC article. Review.
This task is accomplished in part by the production of a large number of T lymphocytes, each bearing a different antigen receptor to match the enormous variety of antigens present in the microbial world. However, because antigen receptor diversity is generated by …
This task is accomplished in part by the production of a large number of T lymphocytes, each bearing a different antigen recep …
Use of adoptive transfer of T-cell-antigen-receptor-transgenic T cell for the study of T-cell activation in vivo.
Pape KA, Kearney ER, Khoruts A, Mondino A, Merica R, Chen ZM, Ingulli E, White J, Johnson JG, Jenkins MK. Pape KA, et al. Among authors: khoruts a. Immunol Rev. 1997 Apr;156:67-78. doi: 10.1111/j.1600-065x.1997.tb00959.x. Immunol Rev. 1997. PMID: 9176700 Review.
We have used this system to show that naive T cells are initially activated within the T-cell zones of secondary lymphoid tissue to proliferate in a B7-dependent manner. ...Our results indicate that inflammatory mediators play a key role in regulating the anatomic l …
We have used this system to show that naive T cells are initially activated within the T-cell zones of secondary lymphoid tissue to prolifer …
In vivo detection of dendritic cell antigen presentation to CD4(+) T cells.
Ingulli E, Mondino A, Khoruts A, Jenkins MK. Ingulli E, et al. Among authors: khoruts a. J Exp Med. 1997 Jun 16;185(12):2133-41. doi: 10.1084/jem.185.12.2133. J Exp Med. 1997. PMID: 9182685 Free PMC article.
Injection of OVA peptide-pulsed DC caused the specific T cells to produce IL-2 in vivo, proliferate, and differentiate into effector cells capable of causing a delayed-type hypersensitivity reaction. ...
Injection of OVA peptide-pulsed DC caused the specific T cells to produce IL-2 in vivo, proliferate, and differentiate into effector cells c …
Inflammatory cytokines enhance the in vivo clonal expansion and differentiation of antigen-activated CD4+ T cells.
Pape KA, Khoruts A, Mondino A, Jenkins MK. Pape KA, et al. Among authors: khoruts a. J Immunol. 1997 Jul 15;159(2):591-8. J Immunol. 1997. PMID: 9218573
Injection of soluble Ag induced a transient accumulation of Ag-specific T cells in lymphoid tissue. If bacterial LPS was present during this period, enhanced numbers of Ag-specific T cells accumulated, migrated into B cell-rich follicles, and provided help for Ab productio …
Injection of soluble Ag induced a transient accumulation of Ag-specific T cells in lymphoid tissue. If bacterial LPS was present duri …
A natural immunological adjuvant enhances T cell clonal expansion through a CD28-dependent, interleukin (IL)-2-independent mechanism.
Khoruts A, Mondino A, Pape KA, Reiner SL, Jenkins MK. Khoruts A, et al. J Exp Med. 1998 Jan 19;187(2):225-36. doi: 10.1084/jem.187.2.225. J Exp Med. 1998. PMID: 9432980 Free PMC article.
Injection of Ag and LPS, a natural immunological adjuvant, enhanced IL-2 production and LN accumulation of wild-type, Ag-specific T cells but had no significant effect on CD28-deficient, Ag-specific T cells. ...These results indicate that adjuvants improve T cell prolifera …
Injection of Ag and LPS, a natural immunological adjuvant, enhanced IL-2 production and LN accumulation of wild-type, Ag-specific T c …
Direct evidence that functionally impaired CD4+ T cells persist in vivo following induction of peripheral tolerance.
Pape KA, Merica R, Mondino A, Khoruts A, Jenkins MK. Pape KA, et al. Among authors: khoruts a. J Immunol. 1998 May 15;160(10):4719-29. J Immunol. 1998. PMID: 9590217
Although injection of OVA peptide in the absence of adjuvant caused a transient expansion and deletion of the Ag-specific T cells, a population that showed signs of prior activation persisted in the lymphoid tissues for several months. ...Therefore, our results prov …
Although injection of OVA peptide in the absence of adjuvant caused a transient expansion and deletion of the Ag-specific T cells, …
Antigen-specific CD4+ T cells that survive after the induction of peripheral tolerance possess an intrinsic lymphokine production defect.
Pape KA, Khoruts A, Ingulli E, Mondino A, Merica R, Jenkins MK. Pape KA, et al. Among authors: khoruts a. Novartis Found Symp. 1998;215:103-13; discussion 113-9, 186-90. doi: 10.1002/9780470515525.ch8. Novartis Found Symp. 1998. PMID: 9760574 Review.
Injection of soluble foreign antigen without an adjuvant induces a state of antigen-specific immunological unresponsiveness. ...The remaining OVA-specific T cells had converted to a memory phenotype but were poorly responsive in vivo as evidenced by a failure …
Injection of soluble foreign antigen without an adjuvant induces a state of antigen-specific immunological unresponsiveness. ...The r …
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