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Mast Cell Activation Disease and Microbiotic Interactions.
Afrin LB, Khoruts A. Afrin LB, et al. Among authors: khoruts a. Clin Ther. 2015 May 1;37(5):941-53. doi: 10.1016/j.clinthera.2015.02.008. Epub 2015 Mar 12. Clin Ther. 2015. PMID: 25773459 Review.
METHODS: A search for all studies on interactions between mast cells, mast cell activation disease, and microbiota published on pubmed.gov and scholar.google.com between 1960 and 2015 was conducted using the search terms mast cell, mastocyte, mastocytosis, mast cell activa …
METHODS: A search for all studies on interactions between mast cells, mast cell activation disease, and microbiota published on pubme …
The Impact of Regulatory Policies on the Future of Fecal Microbiota Transplantation.
Khoruts A, Hoffmann DE, Palumbo FB. Khoruts A, et al. J Law Med Ethics. 2019 Dec;47(4):482-504. doi: 10.1177/1073110519897726. J Law Med Ethics. 2019. PMID: 31957587
In this article, the authors explore the impact of a potential future regulatory decision by FDA whether or not to continue its enforcement discretion policy allowing physicians to perform, and stool banks to sell, stool product for fecal microbiota transplantation as a
In this article, the authors explore the impact of a potential future regulatory decision by FDA whether or not to continue its enfor …
The anatomy of T-cell activation and tolerance.
Mondino A, Khoruts A, Jenkins MK. Mondino A, et al. Among authors: khoruts a. Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2245-52. doi: 10.1073/pnas.93.6.2245. Proc Natl Acad Sci U S A. 1996. PMID: 8637857 Free PMC article. Review.
This task is accomplished in part by the production of a large number of T lymphocytes, each bearing a different antigen receptor to match the enormous variety of antigens present in the microbial world. However, because antigen receptor diversity is generated by …
This task is accomplished in part by the production of a large number of T lymphocytes, each bearing a different antigen recep …
Use of adoptive transfer of T-cell-antigen-receptor-transgenic T cell for the study of T-cell activation in vivo.
Pape KA, Kearney ER, Khoruts A, Mondino A, Merica R, Chen ZM, Ingulli E, White J, Johnson JG, Jenkins MK. Pape KA, et al. Among authors: khoruts a. Immunol Rev. 1997 Apr;156:67-78. doi: 10.1111/j.1600-065x.1997.tb00959.x. Immunol Rev. 1997. PMID: 9176700 Review.
We have used this system to show that naive T cells are initially activated within the T-cell zones of secondary lymphoid tissue to proliferate in a B7-dependent manner. ...Our results indicate that inflammatory mediators play a key role in regulating the anatomic l …
We have used this system to show that naive T cells are initially activated within the T-cell zones of secondary lymphoid tissue to prolifer …
In vivo activation of antigen-specific CD4 T cells.
Jenkins MK, Khoruts A, Ingulli E, Mueller DL, McSorley SJ, Reinhardt RL, Itano A, Pape KA. Jenkins MK, et al. Among authors: khoruts a. Annu Rev Immunol. 2001;19:23-45. doi: 10.1146/annurev.immunol.19.1.23. Annu Rev Immunol. 2001. PMID: 11244029 Review.
Once stimulated by a dendritic cell, antigen-specific CD4 T cells produce IL-2 but proliferate in an IL-2--independent fashion. ...However, in the presence of inflammation, a population of memory T cells survives. This population is composed of two functional classe …
Once stimulated by a dendritic cell, antigen-specific CD4 T cells produce IL-2 but proliferate in an IL-2--independent fashion. ...Ho …
Changes in the composition of the human fecal microbiome after bacteriotherapy for recurrent Clostridium difficile-associated diarrhea.
Khoruts A, Dicksved J, Jansson JK, Sadowsky MJ. Khoruts A, et al. J Clin Gastroenterol. 2010 May-Jun;44(5):354-60. doi: 10.1097/MCG.0b013e3181c87e02. J Clin Gastroenterol. 2010. PMID: 20048681
In this study, we used terminal-restriction fragment length polymorphism and 16S rRNA gene sequencing approaches to characterize the bacterial composition of the colonic microflora in a patient suffering from recurrent CDAD before and after treatment by fecal transplantati …
In this study, we used terminal-restriction fragment length polymorphism and 16S rRNA gene sequencing approaches to characterize the bacteri …
Faecal microbiota transplantation in 2013: developing human gut microbiota as a class of therapeutics.
Khoruts A. Khoruts A. Nat Rev Gastroenterol Hepatol. 2014 Feb;11(2):79-80. doi: 10.1038/nrgastro.2013.231. Epub 2013 Dec 3. Nat Rev Gastroenterol Hepatol. 2014. PMID: 24296579 Review.
The primary focus remains on treatment of Clostridium difficile infection—new applications are beginning to emerge, but a long journey remains ahead....
The primary focus remains on treatment of Clostridium difficile infection—new applications are beginning to emerge, but a long journe …
Emergence of fecal microbiota transplantation as an approach to repair disrupted microbial gut ecology.
Khoruts A, Weingarden AR. Khoruts A, et al. Immunol Lett. 2014 Dec;162(2 Pt A):77-81. doi: 10.1016/j.imlet.2014.07.016. Epub 2014 Aug 10. Immunol Lett. 2014. PMID: 25106113 Free PMC article. Review.
We anticipate that this form of therapy represents merely the first entry into a new class of therapeutics. There is great interest in application of FMT or defined microbial consortia to treatment of many diseases associated with dysbiosis. ...
We anticipate that this form of therapy represents merely the first entry into a new class of therapeutics. There is great interest i …
Introduction to special issue on microbiome influences on host immunity.
McSorley SJ, Khoruts A. McSorley SJ, et al. Among authors: khoruts a. Immunol Lett. 2014 Dec;162(2 Pt A):1-2. doi: 10.1016/j.imlet.2014.08.006. Epub 2014 Aug 12. Immunol Lett. 2014. PMID: 25124961 No abstract available.
Development of fecal microbiota transplantation suitable for mainstream medicine.
Khoruts A, Sadowsky MJ, Hamilton MJ. Khoruts A, et al. Clin Gastroenterol Hepatol. 2015 Feb;13(2):246-50. doi: 10.1016/j.cgh.2014.11.014. Epub 2014 Nov 20. Clin Gastroenterol Hepatol. 2015. PMID: 25460566 Review.
Although it can be relatively simple to perform, a number of challenges need to be overcome before this procedure is widely accepted in mainstream clinical practice. ...Standardized fecal microbiota is being developed as a therapeutic agent, although it clearly chal …
Although it can be relatively simple to perform, a number of challenges need to be overcome before this procedure is widely accepted …
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