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Induction of cardiac fibroblast lysyl oxidase by TGF-β1 requires PI3K/Akt, Smad3, and MAPK signaling.
Voloshenyuk TG, Landesman ES, Khoutorova E, Hart AD, Gardner JD. Voloshenyuk TG, et al. Among authors: khoutorova e. Cytokine. 2011 Jul;55(1):90-7. doi: 10.1016/j.cyto.2011.03.024. Epub 2011 Apr 17. Cytokine. 2011. PMID: 21498085
Alcohol modulation of cardiac matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs favors collagen accumulation.
El Hajj EC, El Hajj MC, Voloshenyuk TG, Mouton AJ, Khoutorova E, Molina PE, Gilpin NW, Gardner JD. El Hajj EC, et al. Among authors: khoutorova e. Alcohol Clin Exp Res. 2014 Feb;38(2):448-56. doi: 10.1111/acer.12239. Epub 2013 Aug 19. Alcohol Clin Exp Res. 2014. PMID: 24033327 Free PMC article.
TNF-α increases cardiac fibroblast lysyl oxidase expression through TGF-β and PI3Kinase signaling pathways.
Voloshenyuk TG, Hart AD, Khoutorova E, Gardner JD. Voloshenyuk TG, et al. Among authors: khoutorova e. Biochem Biophys Res Commun. 2011 Sep 23;413(2):370-5. doi: 10.1016/j.bbrc.2011.08.109. Epub 2011 Aug 27. Biochem Biophys Res Commun. 2011. PMID: 21893029