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Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me).
Yue P, Zhou Z, Khuri FR, Sun SY. Yue P, et al. Among authors: khuri fr. Cancer Biol Ther. 2006 May;5(5):492-7. doi: 10.4161/cbt.5.5.2565. Epub 2006 May 2. Cancer Biol Ther. 2006. PMID: 16582599
A phase 1 Bayesian dose selection study of bortezomib and sunitinib in patients with refractory solid tumor malignancies.
Harvey RD, Owonikoko TK, Lewis CM, Akintayo A, Chen Z, Tighiouart M, Ramalingam SS, Fanucchi MP, Nadella P, Rogatko A, Shin DM, El-Rayes B, Khuri FR, Kauh JS. Harvey RD, et al. Among authors: khuri fr. Br J Cancer. 2013 Mar 5;108(4):762-5. doi: 10.1038/bjc.2012.604. Epub 2013 Jan 15. Br J Cancer. 2013. PMID: 23322195 Free PMC article. Clinical Trial.
Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin.
Elf S, Lin R, Xia S, Pan Y, Shan C, Wu S, Lonial S, Gaddh M, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Boggon TJ, Fan J, Chen J. Elf S, et al. Among authors: khuri fr. Oncogene. 2017 Jan 12;36(2):254-262. doi: 10.1038/onc.2016.196. Epub 2016 Jun 6. Oncogene. 2017. PMID: 27270429 Free PMC article.
Inhibition of B-Raf/MEK/ERK signaling suppresses DR5 expression and impairs response of cancer cells to DR5-mediated apoptosis and T cell-induced killing.
Oh YT, Deng J, Yue P, Owonikoko TK, Khuri FR, Sun SY. Oh YT, et al. Among authors: khuri fr. Oncogene. 2016 Jan 28;35(4):459-67. doi: 10.1038/onc.2015.97. Epub 2015 Apr 13. Oncogene. 2016. PMID: 25867065 Free PMC article.
OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc.
Ivanov AA, Gonzalez-Pecchi V, Khuri LF, Niu Q, Wang Y, Xu Y, Bai Y, Mo X, Prochownik EV, Johns MA, Du Y, Khuri FR, Fu H. Ivanov AA, et al. Among authors: khuri lf, khuri fr. Oncogene. 2017 Oct 19;36(42):5852-5860. doi: 10.1038/onc.2017.180. Epub 2017 Jun 19. Oncogene. 2017. PMID: 28628118 Free PMC article.
Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis.
Jin L, Chun J, Pan C, Alesi GN, Li D, Magliocca KR, Kang Y, Chen ZG, Shin DM, Khuri FR, Fan J, Kang S. Jin L, et al. Among authors: khuri fr. Oncogene. 2017 Jul 6;36(27):3797-3806. doi: 10.1038/onc.2017.6. Epub 2017 Feb 20. Oncogene. 2017. PMID: 28218905 Free PMC article.
RSK2 signals through stathmin to promote microtubule dynamics and tumor metastasis.
Alesi GN, Jin L, Li D, Magliocca KR, Kang Y, Chen ZG, Shin DM, Khuri FR, Kang S. Alesi GN, et al. Among authors: khuri fr. Oncogene. 2016 Oct 13;35(41):5412-5421. doi: 10.1038/onc.2016.79. Epub 2016 Apr 4. Oncogene. 2016. PMID: 27041561 Free PMC article.
Oncogenic role of EAPII in lung cancer development and its activation of the MAPK-ERK pathway.
Li C, Fan S, Owonikoko TK, Khuri FR, Sun SY, Li R. Li C, et al. Among authors: khuri fr. Oncogene. 2011 Sep 1;30(35):3802-12. doi: 10.1038/onc.2011.94. Epub 2011 Apr 11. Oncogene. 2011. PMID: 21478903 Free PMC article.
14-3-3 Integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cells.
Dong S, Kang S, Gu TL, Kardar S, Fu H, Lonial S, Khoury HJ, Khuri F, Chen J. Dong S, et al. Among authors: khuri f. Blood. 2007 Jul 1;110(1):360-9. doi: 10.1182/blood-2006-12-065615. Epub 2007 Mar 27. Blood. 2007. PMID: 17389761 Free PMC article.
Implication of protein kinase B/Akt and Bcl-2/Bcl-XL suppression by the farnesyl transferase inhibitor SCH66336 in apoptosis induction in squamous carcinoma cells.
Chun KH, Lee HY, Hassan K, Khuri F, Hong WK, Lotan R. Chun KH, et al. Among authors: khuri f. Cancer Res. 2003 Aug 15;63(16):4796-800. Cancer Res. 2003. PMID: 12941797
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