Kidger AM - Search Results

1

Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors.

Lochhead PA, Tucker JA, Tatum NJ, Wang J, Oxley D, Kidger AM, Johnson VP, Cassidy MA, Gray NS, Noble MEM, Cook SJ. Lochhead PA, et al. Among authors: kidger am. Nat Commun. 2020 Mar 13;11(1):1383. doi: 10.1038/s41467-020-15031-3. Nat Commun. 2020. PMID: 32170057 Free PMC article.

2

Visualization of Endogenous ERK1/2 in Cells with a Bioorthogonal Covalent Probe.

Sipthorp J, Lebraud H, Gilley R, Kidger AM, Okkenhaug H, Saba-El-Leil M, Meloche S, Caunt CJ, Cook SJ, Heightman TD. Sipthorp J, et al. Among authors: kidger am. Bioconjug Chem. 2017 Jun 21;28(6):1677-1683. doi: 10.1021/acs.bioconjchem.7b00152. Epub 2017 May 12. Bioconjug Chem. 2017. PMID: 28449575 Free article.

3

De-RSKing ERK - regulation of ERK1/2-RSK dissociation by phosphorylation within a disordered motif.

Kidger AM, Cook SJ. Kidger AM, et al. FEBS J. 2018 Jan;285(1):42-45. doi: 10.1111/febs.14344. FEBS J. 2018. PMID: 29314599 Free article.

4

ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathway.

Kidger AM, Sipthorp J, Cook SJ. Kidger AM, et al. Pharmacol Ther. 2018 Jul;187:45-60. doi: 10.1016/j.pharmthera.2018.02.007. Epub 2018 Feb 16. Pharmacol Ther. 2018. PMID: 29454854 Review.

5

An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis.

Odle RI, Walker SA, Oxley D, Kidger AM, Balmanno K, Gilley R, Okkenhaug H, Florey O, Ktistakis NT, Cook SJ. Odle RI, et al. Among authors: kidger am. Mol Cell. 2020 Jan 16;77(2):228-240.e7. doi: 10.1016/j.molcel.2019.10.016. Epub 2019 Nov 13. Mol Cell. 2020. PMID: 31733992 Free PMC article.

6

Dual-Mechanism ERK1/2 Inhibitors Exploit a Distinct Binding Mode to Block Phosphorylation and Nuclear Accumulation of ERK1/2.

Kidger AM, Munck JM, Saini HK, Balmanno K, Minihane E, Courtin A, Graham B, O'Reilly M, Odle R, Cook SJ. Kidger AM, et al. Mol Cancer Ther. 2020 Feb;19(2):525-539. doi: 10.1158/1535-7163.MCT-19-0505. Epub 2019 Nov 20. Mol Cancer Ther. 2020. PMID: 31748345

7

ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1.

Balmanno K, Kidger AM, Byrne DP, Sale MJ, Nassman N, Eyers PA, Cook SJ. Balmanno K, et al. Among authors: kidger am. Biochem J. 2023 May 15;480(9):587-605. doi: 10.1042/BCJ20220598. Biochem J. 2023. PMID: 37018014 Free PMC article.

8

Dual-specificity MAP kinase phosphatases in health and disease.

Seternes OM, Kidger AM, Keyse SM. Seternes OM, et al. Among authors: kidger am. Biochim Biophys Acta Mol Cell Res. 2019 Jan;1866(1):124-143. doi: 10.1016/j.bbamcr.2018.09.002. Epub 2018 Sep 8. Biochim Biophys Acta Mol Cell Res. 2019. PMID: 30401534 Free PMC article. Review.

9

Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression.

Rushworth LK, Kidger AM, Delavaine L, Stewart G, van Schelven S, Davidson J, Bryant CJ, Caddye E, East P, Caunt CJ, Keyse SM. Rushworth LK, et al. Among authors: kidger am. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18267-72. doi: 10.1073/pnas.1420159112. Epub 2014 Dec 8. Proc Natl Acad Sci U S A. 2014. PMID: 25489104 Free PMC article.

10

Visualizing and Quantitating the Spatiotemporal Regulation of Ras/ERK Signaling by Dual-Specificity Mitogen-Activated Protein Phosphatases (MKPs).

Caunt CJ, Kidger AM, Keyse SM. Caunt CJ, et al. Among authors: kidger am. Methods Mol Biol. 2016;1447:197-215. doi: 10.1007/978-1-4939-3746-2_12. Methods Mol Biol. 2016. PMID: 27514808

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