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In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukin-12 (IL-12) but not on IL-12 p70.
Elkins KL, Cooper A, Colombini SM, Cowley SC, Kieffer TL. Elkins KL, et al. Infect Immun. 2002 Apr;70(4):1936-48. doi: 10.1128/iai.70.4.1936-1948.2002. Infect Immun. 2002. PMID: 11895957 Free PMC article.
Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells.
Bailey JR, Sedaghat AR, Kieffer T, Brennan T, Lee PK, Wind-Rotolo M, Haggerty CM, Kamireddi AR, Liu Y, Lee J, Persaud D, Gallant JE, Cofrancesco J Jr, Quinn TC, Wilke CO, Ray SC, Siliciano JD, Nettles RE, Siliciano RF. Bailey JR, et al. J Virol. 2006 Jul;80(13):6441-57. doi: 10.1128/JVI.00591-06. J Virol. 2006. PMID: 16775332 Free PMC article.
Genotypic and phenotypic analyses of hepatitis C virus variants observed in clinical studies of VX-222, a nonnucleoside NS5B polymerase inhibitor.
Jiang M, Zhang EZ, Ardzinski A, Tigges A, Davis A, Sullivan JC, Nelson M, Spanks J, Dorrian J, Nicolas O, Bartels DJ, Rao BG, Rijnbrand R, Kieffer TL. Jiang M, et al. Among authors: kieffer tl. Antimicrob Agents Chemother. 2014 Sep;58(9):5456-65. doi: 10.1128/AAC.03052-14. Epub 2014 Jun 30. Antimicrob Agents Chemother. 2014. PMID: 24982088 Free PMC article. Clinical Trial.
In vitro phenotypic characterization of hepatitis C virus NS3 protease variants observed in clinical studies of telaprevir.
Jiang M, Mani N, Lin C, Ardzinski A, Nelson M, Reagan D, Bartels D, Zhou Y, Nicolas O, Rao BG, Müh U, Hanzelka B, Tigges A, Rijnbrand R, Kieffer TL. Jiang M, et al. Antimicrob Agents Chemother. 2013 Dec;57(12):6236-45. doi: 10.1128/AAC.01578-13. Epub 2013 Oct 7. Antimicrob Agents Chemother. 2013. PMID: 24100495 Free PMC article.
Viral resistance to specifically targeted antiviral therapies for hepatitis C (STAT-Cs).
Kieffer TL, Kwong AD, Picchio GR. Kieffer TL, et al. J Antimicrob Chemother. 2010 Feb;65(2):202-12. doi: 10.1093/jac/dkp388. Epub 2009 Nov 10. J Antimicrob Chemother. 2010. PMID: 19903720 Review.
A comparison of 454 sequencing and clonal sequencing for the characterization of hepatitis C virus NS3 variants.
Ho CKY, Welkers MRA, Thomas XV, Sullivan JC, Kieffer TL, Reesink HW, Rebers SPH, de Jong MD, Schinkel J, Molenkamp R. Ho CKY, et al. Among authors: kieffer tl. J Virol Methods. 2015 Jul;219:28-37. doi: 10.1016/j.jviromet.2015.03.018. Epub 2015 Mar 26. J Virol Methods. 2015. PMID: 25818622
Modeling viral evolutionary dynamics after telaprevir-based treatment.
Haseltine EL, De Meyer S, Dierynck I, Bartels DJ, Ghys A, Davis A, Zhang EZ, Tigges AM, Spanks J, Picchio G, Kieffer TL, Sullivan JC. Haseltine EL, et al. Among authors: kieffer tl. PLoS Comput Biol. 2014 Aug 7;10(8):e1003772. doi: 10.1371/journal.pcbi.1003772. eCollection 2014 Aug. PLoS Comput Biol. 2014. PMID: 25101970 Free PMC article.
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