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Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.
Kiepiela P, Leslie AJ, Honeyborne I, Ramduth D, Thobakgale C, Chetty S, Rathnavalu P, Moore C, Pfafferott KJ, Hilton L, Zimbwa P, Moore S, Allen T, Brander C, Addo MM, Altfeld M, James I, Mallal S, Bunce M, Barber LD, Szinger J, Day C, Klenerman P, Mullins J, Korber B, Coovadia HM, Walker BD, Goulder PJ. Kiepiela P, et al. Nature. 2004 Dec 9;432(7018):769-75. doi: 10.1038/nature03113. Nature. 2004. PMID: 15592417
Here we show that variation in viral set-point, in absolute CD4 count and, by inference, in rate of disease progression in the cohort, is strongly associated with particular HLA-B but not HLA-A allele expression (P < 0.0001 and P = 0.91, respectively). Moreover, substantially greater selection pressure is imposed on HIV-1 by HLA-B alleles than by HLA-A (4.4-fold, P = 0.0003). ...
Here we show that variation in viral set-point, in absolute CD4 count and, by inference, in rate of disease progression in the cohort, is st …
HIV evolution: CTL escape mutation and reversion after transmission.
Leslie AJ, Pfafferott KJ, Chetty P, Draenert R, Addo MM, Feeney M, Tang Y, Holmes EC, Allen T, Prado JG, Altfeld M, Brander C, Dixon C, Ramduth D, Jeena P, Thomas SA, St John A, Roach TA, Kupfer B, Luzzi G, Edwards A, Taylor G, Lyall H, Tudor-Williams G, Novelli V, Martinez-Picado J, Kiepiela P, Walker BD, Goulder PJ. Leslie AJ, et al. Among authors: Kiepiela P. Nat Med. 2004 Mar;10(3):282-9. doi: 10.1038/nm992. Epub 2004 Feb 8. Nat Med. 2004. PMID: 14770175
Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.
Draenert R, Le Gall S, Pfafferott KJ, Leslie AJ, Chetty P, Brander C, Holmes EC, Chang SC, Feeney ME, Addo MM, Ruiz L, Ramduth D, Jeena P, Altfeld M, Thomas S, Tang Y, Verrill CL, Dixon C, Prado JG, Kiepiela P, Martinez-Picado J, Walker BD, Goulder PJ. Draenert R, et al. Among authors: Kiepiela P. J Exp Med. 2004 Apr 5;199(7):905-15. doi: 10.1084/jem.20031982. J Exp Med. 2004. PMID: 15067030 Free PMC article.
Laboratory markers associated with progression of HIV infection.
Kiepiela P, Smith AN, Rosenberg E. Kiepiela P, et al. Best Pract Res Clin Obstet Gynaecol. 2005 Apr;19(2):243-54. doi: 10.1016/j.bpobgyn.2004.11.002. Epub 2005 Jan 25. Best Pract Res Clin Obstet Gynaecol. 2005. PMID: 15778113 Retracted. Review.
Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA.
Leslie A, Kavanagh D, Honeyborne I, Pfafferott K, Edwards C, Pillay T, Hilton L, Thobakgale C, Ramduth D, Draenert R, Le Gall S, Luzzi G, Edwards A, Brander C, Sewell AK, Moore S, Mullins J, Moore C, Mallal S, Bhardwaj N, Yusim K, Phillips R, Klenerman P, Korber B, Kiepiela P, Walker B, Goulder P. Leslie A, et al. Among authors: Kiepiela P. J Exp Med. 2005 Mar 21;201(6):891-902. doi: 10.1084/jem.20041455. J Exp Med. 2005. PMID: 15781581 Free PMC article.
HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load.
Frahm N, Adams S, Kiepiela P, Linde CH, Hewitt HS, Lichterfeld M, Sango K, Brown NV, Pae E, Wurcel AG, Altfeld M, Feeney ME, Allen TM, Roach T, St John MA, Daar ES, Rosenberg E, Korber B, Marincola F, Walker BD, Goulder PJ, Brander C. Frahm N, et al. Among authors: Kiepiela P. J Virol. 2005 Aug;79(16):10218-25. doi: 10.1128/JVI.79.16.10218-10225.2005. J Virol. 2005. PMID: 16051815 Free PMC article.
Differential immunogenicity of HIV-1 clade C proteins in eliciting CD8+ and CD4+ cell responses.
Ramduth D, Chetty P, Mngquandaniso NC, Nene N, Harlow JD, Honeyborne I, Ntumba N, Gappoo S, Henry C, Jeena P, Addo MM, Altfeld M, Brander C, Day C, Coovadia H, Kiepiela P, Goulder P, Walker B. Ramduth D, et al. Among authors: Kiepiela P. J Infect Dis. 2005 Nov 1;192(9):1588-96. doi: 10.1086/496894. Epub 2005 Sep 30. J Infect Dis. 2005. PMID: 16206073
However, the median viral load in subjects in whom Gag was the dominant CD8+ T cell target was significantly lower than that in subjects in whom non-Gag proteins were the main target (P=.007). ...
However, the median viral load in subjects in whom Gag was the dominant CD8+ T cell target was significantly lower than that in subjects in …
Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes.
Frahm N, Kiepiela P, Adams S, Linde CH, Hewitt HS, Sango K, Feeney ME, Addo MM, Lichterfeld M, Lahaie MP, Pae E, Wurcel AG, Roach T, St John MA, Altfeld M, Marincola FM, Moore C, Mallal S, Carrington M, Heckerman D, Allen TM, Mullins JI, Korber BT, Goulder PJ, Walker BD, Brander C. Frahm N, et al. Among authors: Kiepiela P. Nat Immunol. 2006 Feb;7(2):173-8. doi: 10.1038/ni1281. Epub 2005 Dec 20. Nat Immunol. 2006. PMID: 16369537
Motif inference reveals optimal CTL epitopes presented by HLA class I alleles highly prevalent in southern Africa.
Honeyborne I, Rathod A, Buchli R, Ramduth D, Moodley E, Rathnavalu P, Chetty S, Day C, Brander C, Hildebrand W, Walker BD, Kiepiela P, Goulder PJ. Honeyborne I, et al. Among authors: Kiepiela P. J Immunol. 2006 Apr 15;176(8):4699-705. doi: 10.4049/jimmunol.176.8.4699. J Immunol. 2006. PMID: 16585563
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