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Characterization and modulation of anti-αβTCR antibodies and their respective binding sites at the βTCR chain to enrich engineered T cells.
Mol Ther Methods Clin Dev. 2021 Jun 24;22:388-400. doi: 10.1016/j.omtm.2021.06.011. eCollection 2021 Sep 10.
Mol Ther Methods Clin Dev. 2021.
PMID: 34514030
Free PMC article.
Identification of a tumor-specific allo-HLA-restricted γδTCR.
Kierkels GJJ, Scheper W, Meringa AD, Johanna I, Beringer DX, Janssen A, Schiffler M, Aarts-Riemens T, Kramer L, Straetemans T, Heijhuurs S, Leusen JHW, San José E, Fuchs K, Griffioen M, Falkenburg JH, Bongiovanni L, de Bruin A, Vargas-Diaz D, Altelaar M, Heck AJR, Shultz LD, Ishikawa F, Nishimura MI, Sebestyén Z, Kuball J.
Kierkels GJJ, et al.
Blood Adv. 2019 Oct 8;3(19):2870-2882. doi: 10.1182/bloodadvances.2019032409.
Blood Adv. 2019.
PMID: 31585951
Free PMC article.
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GMP-Grade Manufacturing of T Cells Engineered to Express a Defined γδTCR.
Straetemans T, Kierkels GJJ, Doorn R, Jansen K, Heijhuurs S, Dos Santos JM, van Muyden ADD, Vie H, Clemenceau B, Raymakers R, de Witte M, Sebestyén Z, Kuball J.
Straetemans T, et al. Among authors: kierkels gjj.
Front Immunol. 2018 May 30;9:1062. doi: 10.3389/fimmu.2018.01062. eCollection 2018.
Front Immunol. 2018.
PMID: 29899740
Free PMC article.
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The next step toward GMP-grade production of engineered immune cells.
Kierkels GJ, Straetemans T, de Witte MA, Kuball J.
Kierkels GJ, et al.
Oncoimmunology. 2015 Aug 27;5(2):e1076608. doi: 10.1080/2162402X.2015.1076608. eCollection 2016 Feb.
Oncoimmunology. 2015.
PMID: 27057450
Free PMC article.
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Orchestrating an immune response against cancer with engineered immune cells expressing αβTCRs, CARs, and innate immune receptors: an immunological and regulatory challenge.
de Witte MA, Kierkels GJ, Straetemans T, Britten CM, Kuball J.
de Witte MA, et al. Among authors: kierkels gj.
Cancer Immunol Immunother. 2015 Jul;64(7):893-902. doi: 10.1007/s00262-015-1710-8. Epub 2015 May 20.
Cancer Immunol Immunother. 2015.
PMID: 25990073
Free PMC article.
Review.
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Cytoplasmic localization of PML particles in laminopathies.
Houben F, De Vos WH, Krapels IP, Coorens M, Kierkels GJ, Kamps MA, Verstraeten VL, Marcelis CL, van den Wijngaard A, Ramaekers FC, Broers JL.
Houben F, et al. Among authors: kierkels gj.
Histochem Cell Biol. 2013 Jan;139(1):119-34. doi: 10.1007/s00418-012-1005-5. Epub 2012 Aug 25.
Histochem Cell Biol. 2013.
PMID: 22918509
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The combination of gefitinib and RAD001 inhibits growth of HER2 overexpressing breast cancer cells and tumors irrespective of trastuzumab sensitivity.
Dragowska WH, Weppler SA, Qadir MA, Wong LY, Franssen Y, Baker JH, Kapanen AI, Kierkels GJ, Masin D, Minchinton AI, Gelmon KA, Bally MB.
Dragowska WH, et al. Among authors: kierkels gj.
BMC Cancer. 2011 Oct 1;11:420. doi: 10.1186/1471-2407-11-420.
BMC Cancer. 2011.
PMID: 21961653
Free PMC article.
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