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Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation.
Young S, Schiffer C, Wagner A, Patz J, Potapenko A, Herrmann L, Nordhoff V, Pock T, Krallmann C, Stallmeyer B, Röpke A, Kierzek M, Biagioni C, Wang T, Haalck L, Deuster D, Hansen JN, Wachten D, Risse B, Behre HM, Schlatt S, Kliesch S, Tüttelmann F, Brenker C, Strünker T. Young S, et al. Among authors: kierzek m. J Clin Invest. 2024 Jan 2;134(1):e173564. doi: 10.1172/JCI173564. J Clin Invest. 2024. PMID: 38165034 Free PMC article.
CRISP2 Is a Regulator of Multiple Aspects of Sperm Function and Male Fertility.
Lim S, Kierzek M, O'Connor AE, Brenker C, Merriner DJ, Okuda H, Volpert M, Gaikwad A, Bianco D, Potter D, Prabhakar R, Strünker T, O'Bryan MK. Lim S, et al. Among authors: kierzek m. Endocrinology. 2019 Apr 1;160(4):915-924. doi: 10.1210/en.2018-01076. Endocrinology. 2019. PMID: 30759213
A novel cross-species inhibitor to study the function of CatSper Ca2+ channels in sperm.
Rennhack A, Schiffer C, Brenker C, Fridman D, Nitao ET, Cheng YM, Tamburrino L, Balbach M, Stölting G, Berger TK, Kierzek M, Alvarez L, Wachten D, Zeng XH, Baldi E, Publicover SJ, Kaupp UB, Strünker T. Rennhack A, et al. Among authors: kierzek m. Br J Pharmacol. 2018 Aug;175(15):3144-3161. doi: 10.1111/bph.14355. Epub 2018 Jun 29. Br J Pharmacol. 2018. PMID: 29723408 Free PMC article.