Kilgour E - Search Results

1

PDH kinase inhibitors: a novel therapy for Type II diabetes?

Mayers RM, Leighton B, Kilgour E. Mayers RM, et al. Among authors: kilgour e. Biochem Soc Trans. 2005 Apr;33(Pt 2):367-70. doi: 10.1042/BST0330367. Biochem Soc Trans. 2005. PMID: 15787608 Review.

2

AZD7545, a novel inhibitor of pyruvate dehydrogenase kinase 2 (PDHK2), activates pyruvate dehydrogenase in vivo and improves blood glucose control in obese (fa/fa) Zucker rats.

Mayers RM, Butlin RJ, Kilgour E, Leighton B, Martin D, Myatt J, Orme JP, Holloway BR. Mayers RM, et al. Among authors: kilgour e. Biochem Soc Trans. 2003 Dec;31(Pt 6):1165-7. doi: 10.1042/bst0311165. Biochem Soc Trans. 2003. PMID: 14641018 Review.

3

AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2.

Morrell JA, Orme J, Butlin RJ, Roche TE, Mayers RM, Kilgour E. Morrell JA, et al. Among authors: kilgour e. Biochem Soc Trans. 2003 Dec;31(Pt 6):1168-70. doi: 10.1042/bst0311168. Biochem Soc Trans. 2003. PMID: 14641019

4

Discovery of a potent, selective, and orally bioavailable acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017).

Scott JS, Bowker SS, Deschoolmeester J, Gerhardt S, Hargreaves D, Kilgour E, Lloyd A, Mayers RM, McCoull W, Newcombe NJ, Ogg D, Packer MJ, Rees A, Revill J, Schofield P, Selmi N, Swales JG, Whittamore PR. Scott JS, et al. Among authors: kilgour e. J Med Chem. 2012 Jun 28;55(12):5951-64. doi: 10.1021/jm300592r. Epub 2012 Jun 19. J Med Chem. 2012. PMID: 22691057

5

Novel acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329).

Scott JS, deSchoolmeester J, Kilgour E, Mayers RM, Packer MJ, Hargreaves D, Gerhardt S, Ogg DJ, Rees A, Selmi N, Stocker A, Swales JG, Whittamore PR. Scott JS, et al. Among authors: kilgour e. J Med Chem. 2012 Nov 26;55(22):10136-47. doi: 10.1021/jm301252n. Epub 2012 Nov 7. J Med Chem. 2012. PMID: 23088558

6

Tissue-specific changes in the ability of insulin and noradrenaline to activate pyruvate dehydrogenase in vivo during lactation in the rat.

Kilgour E, Vernon RG. Kilgour E, et al. Biochem J. 1987 Apr 1;243(1):69-74. doi: 10.1042/bj2430069. Biochem J. 1987. PMID: 3300640 Free PMC article.

7

Requirement for phosphoinositide 3-OH kinase in growth hormone signalling to the mitogen-activated protein kinase and p70s6k pathways.

Kilgour E, Gout I, Anderson NG. Kilgour E, et al. Biochem J. 1996 Apr 15;315 ( Pt 2)(Pt 2):517-22. doi: 10.1042/bj3150517. Biochem J. 1996. PMID: 8615823 Free PMC article.

8

Molecular pathways: fibroblast growth factor signaling: a new therapeutic opportunity in cancer.

Brooks AN, Kilgour E, Smith PD. Brooks AN, et al. Among authors: kilgour e. Clin Cancer Res. 2012 Apr 1;18(7):1855-62. doi: 10.1158/1078-0432.CCR-11-0699. Epub 2012 Mar 2. Clin Cancer Res. 2012. PMID: 22388515 Review.

9

Defect in signal transduction at the level of the plasma membrane accounts for inability of insulin to activate pyruvate dehydrogenase in white adipocytes of lactating rats.

Kilgour E, Vernon RG. Kilgour E, et al. Biochem J. 1988 Jun 15;252(3):667-72. doi: 10.1042/bj2520667. Biochem J. 1988. PMID: 2844153 Free PMC article.

10

Catecholamine activation of pyruvate dehydrogenase in white adipose tissue of the rat in vivo.

Kilgour E, Vernon RG. Kilgour E, et al. Biochem J. 1987 Jan 15;241(2):415-9. doi: 10.1042/bj2410415. Biochem J. 1987. PMID: 3297031 Free PMC article.

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