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The GSK3 hypothesis of Alzheimer's disease.
Hooper C, Killick R, Lovestone S. Hooper C, et al. Among authors: killick r. J Neurochem. 2008 Mar;104(6):1433-9. doi: 10.1111/j.1471-4159.2007.05194.x. Epub 2007 Dec 18. J Neurochem. 2008. PMID: 18088381 Free PMC article. Review.
Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase.
Mudher A, Chapman S, Richardson J, Asuni A, Gibb G, Pollard C, Killick R, Iqbal T, Raymond L, Varndell I, Sheppard P, Makoff A, Gower E, Soden PE, Lewis P, Murphy M, Golde TE, Rupniak HT, Anderton BH, Lovestone S. Mudher A, et al. Among authors: killick r. J Neurosci. 2001 Jul 15;21(14):4987-95. doi: 10.1523/JNEUROSCI.21-14-04987.2001. J Neurosci. 2001. PMID: 11438574 Free PMC article.
Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease.
Busby V, Goossens S, Nowotny P, Hamilton G, Smemo S, Harold D, Turic D, Jehu L, Myers A, Womick M, Woo D, Compton D, Doil LM, Tacey KM, Lau KF, Al-Saraj S, Killick R, Pickering-Brown S, Moore P, Hollingworth P, Archer N, Foy C, Walter S, Lendon C, Iwatsubo T, Morris JC, Norton J, Mann D, Janssens B, Hardy J, O'Donovan M, Jones L, Williams J, Holmans P, Owen MJ, Grupe A, Powell J, van Hengel J, Goate A, Van Roy F, Lovestone S. Busby V, et al. Among authors: killick r. Neuromolecular Med. 2004;5(2):133-46. doi: 10.1385/NMM:5:2:133. Neuromolecular Med. 2004. PMID: 15075440
Glycogen synthase kinase-3 inhibition is integral to long-term potentiation.
Hooper C, Markevich V, Plattner F, Killick R, Schofield E, Engel T, Hernandez F, Anderton B, Rosenblum K, Bliss T, Cooke SF, Avila J, Lucas JJ, Giese KP, Stephenson J, Lovestone S. Hooper C, et al. Among authors: killick r. Eur J Neurosci. 2007 Jan;25(1):81-6. doi: 10.1111/j.1460-9568.2006.05245.x. Eur J Neurosci. 2007. PMID: 17241269
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