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Transient proteolytic modification of mesenchymal stromal cells increases lung clearance rate and targeting to injured tissue.
Kerkelä E, Hakkarainen T, Mäkelä T, Raki M, Kambur O, Kilpinen L, Nikkilä J, Lehtonen S, Ritamo I, Pernu R, Pietilä M, Takalo R, Juvonen T, Bergström K, Kalso E, Valmu L, Laitinen S, Lehenkari P, Nystedt J. Kerkelä E, et al. Among authors: kilpinen l. Stem Cells Transl Med. 2013 Jul;2(7):510-20. doi: 10.5966/sctm.2012-0187. Epub 2013 Jun 3. Stem Cells Transl Med. 2013. PMID: 23734061 Free PMC article.
Extracellular membrane vesicles from umbilical cord blood-derived MSC protect against ischemic acute kidney injury, a feature that is lost after inflammatory conditioning.
Kilpinen L, Impola U, Sankkila L, Ritamo I, Aatonen M, Kilpinen S, Tuimala J, Valmu L, Levijoki J, Finckenberg P, Siljander P, Kankuri E, Mervaala E, Laitinen S. Kilpinen L, et al. J Extracell Vesicles. 2013 Dec 10;2. doi: 10.3402/jev.v2i0.21927. eCollection 2013. J Extracell Vesicles. 2013. PMID: 24349659 Free PMC article.