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SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress.
Kim HS, Patel K, Muldoon-Jacobs K, Bisht KS, Aykin-Burns N, Pennington JD, van der Meer R, Nguyen P, Savage J, Owens KM, Vassilopoulos A, Ozden O, Park SH, Singh KK, Abdulkadir SA, Spitz DR, Deng CX, Gius D. Kim HS, et al. Cancer Cell. 2010 Jan 19;17(1):41-52. doi: 10.1016/j.ccr.2009.11.023. Cancer Cell. 2010. PMID: 20129246 Free PMC article.
Sirt3, mitochondrial ROS, ageing, and carcinogenesis.
Park SH, Ozden O, Jiang H, Cha YI, Pennington JD, Aykin-Burns N, Spitz DR, Gius D, Kim HS. Park SH, et al. Among authors: kim hs. Int J Mol Sci. 2011;12(9):6226-39. doi: 10.3390/ijms12096226. Epub 2011 Sep 23. Int J Mol Sci. 2011. PMID: 22016654 Free PMC article. Review.
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