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The novel methoxetamine analogs N-ethylnorketamine hydrochloride (NENK), 2-MeO-N-ethylketamine hydrochloride (2-MeO-NEK), and 4-MeO-N-ethylketamine hydrochloride (4-MeO-NEK) elicit rapid antidepressant effects via activation of AMPA and 5-HT2 receptors.
Sayson LV, Botanas CJ, Custodio RJP, Abiero A, Kim M, Lee HJ, Kim HJ, Yoo SY, Lee KW, Ryu HW, Acharya S, Kim KM, Lee YS, Cheong JH. Sayson LV, et al. Among authors: kim hj, kim km, kim m. Psychopharmacology (Berl). 2019 Jul;236(7):2201-2210. doi: 10.1007/s00213-019-05219-x. Epub 2019 Mar 19. Psychopharmacology (Berl). 2019. PMID: 30891619
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