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IN-1130, a novel transforming growth factor-beta type I receptor kinase (activin receptor-like kinase 5) inhibitor, promotes regression of fibrotic plaque and corrects penile curvature in a rat model of Peyronie's disease.
Ryu JK, Piao S, Shin HY, Choi MJ, Zhang LW, Jin HR, Kim WJ, Han JY, Hong SS, Park SH, Lee SJ, Kim IH, Lee CR, Kim DK, Mamura M, Kim SJ, Suh JK. Ryu JK, et al. Among authors: kim ih, kim wj, kim dk, kim sj. J Sex Med. 2009 May;6(5):1284-96. doi: 10.1111/j.1743-6109.2009.01216.x. Epub 2009 Mar 18. J Sex Med. 2009. PMID: 19473283
Geldanamycin inhibits TGF-beta signaling through induction of Hsp70.
Yun CH, Yoon SY, Nguyen TT, Cho HY, Kim TH, Kim ST, Kim BC, Hong YS, Kim SJ, Lee HJ. Yun CH, et al. Among authors: kim st, kim bc, kim th, kim sj. Arch Biochem Biophys. 2010 Mar 1;495(1):8-13. doi: 10.1016/ Epub 2009 Dec 6. Arch Biochem Biophys. 2010. PMID: 19995547
TrkC plays an essential role in breast tumor growth and metastasis.
Jin W, Kim GM, Kim MS, Lim MH, Yun C, Jeong J, Nam JS, Kim SJ. Jin W, et al. Among authors: kim gm, kim ms, kim sj. Carcinogenesis. 2010 Nov;31(11):1939-47. doi: 10.1093/carcin/bgq180. Epub 2010 Aug 28. Carcinogenesis. 2010. PMID: 20802235 Free article.
Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis.
Hong S, Kim HY, Kim J, Ha HT, Kim YM, Bae E, Kim TH, Lee KC, Kim SJ. Hong S, et al. Among authors: kim hy, kim ym, kim th, kim sj, kim j. J Biol Chem. 2013 Feb 1;288(5):3560-70. doi: 10.1074/jbc.M112.400408. Epub 2012 Dec 19. J Biol Chem. 2013. PMID: 23255602 Free PMC article.
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