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Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes.
Kim YB, Nikoulina SE, Ciaraldi TP, Henry RR, Kahn BB. Kim YB, et al. J Clin Invest. 1999 Sep;104(6):733-41. doi: 10.1172/JCI6928. J Clin Invest. 1999. PMID: 10491408 Free PMC article.
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus.
Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferré P, Birnbaum MJ, Stuck BJ, Kahn BB. Minokoshi Y, et al. Among authors: kim yb. Nature. 2004 Apr 1;428(6982):569-74. doi: 10.1038/nature02440. Nature. 2004. PMID: 15058305
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.
Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB, Zheng XX, Wheeler MB, Shulman GI, Chan CB, Lowell BB. Zhang CY, et al. Among authors: kim yb. Cell. 2001 Jun 15;105(6):745-55. doi: 10.1016/s0092-8674(01)00378-6. Cell. 2001. PMID: 11440717
Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance.
Zabolotny JM, Kim YB, Peroni OD, Kim JK, Pani MA, Boss O, Klaman LD, Kamatkar S, Shulman GI, Kahn BB, Neel BG. Zabolotny JM, et al. Among authors: kim yb, kim jk. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5187-92. doi: 10.1073/pnas.071050398. Epub 2001 Apr 17. Proc Natl Acad Sci U S A. 2001. PMID: 11309481 Free PMC article.
Uncoupling protein 3 (UCP3) stimulates glucose uptake in muscle cells through a phosphoinositide 3-kinase-dependent mechanism.
Huppertz C, Fischer BM, Kim YB, Kotani K, Vidal-Puig A, Slieker LJ, Sloop KW, Lowell BB, Kahn BB. Huppertz C, et al. Among authors: kim yb. J Biol Chem. 2001 Apr 20;276(16):12520-9. doi: 10.1074/jbc.M011708200. Epub 2001 Jan 12. J Biol Chem. 2001. PMID: 11278970
Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice.
Klaman LD, Boss O, Peroni OD, Kim JK, Martino JL, Zabolotny JM, Moghal N, Lubkin M, Kim YB, Sharpe AH, Stricker-Krongrad A, Shulman GI, Neel BG, Kahn BB. Klaman LD, et al. Among authors: kim jk, kim yb. Mol Cell Biol. 2000 Aug;20(15):5479-89. doi: 10.1128/mcb.20.15.5479-5489.2000. Mol Cell Biol. 2000. PMID: 10891488 Free PMC article.
Overexpression of protein-tyrosine phosphatase-1B in adipocytes inhibits insulin-stimulated phosphoinositide 3-kinase activity without altering glucose transport or Akt/Protein kinase B activation.
Venable CL, Frevert EU, Kim YB, Fischer BM, Kamatkar S, Neel BG, Kahn BB. Venable CL, et al. Among authors: kim yb. J Biol Chem. 2000 Jun 16;275(24):18318-26. doi: 10.1074/jbc.M908392199. J Biol Chem. 2000. PMID: 10751417
In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin.
Kim YB, Uotani S, Pierroz DD, Flier JS, Kahn BB. Kim YB, et al. Endocrinology. 2000 Jul;141(7):2328-39. doi: 10.1210/endo.141.7.7536. Endocrinology. 2000. PMID: 10875232
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver.
Abel ED, Peroni O, Kim JK, Kim YB, Boss O, Hadro E, Minnemann T, Shulman GI, Kahn BB. Abel ED, et al. Among authors: kim jk, kim yb. Nature. 2001 Feb 8;409(6821):729-33. doi: 10.1038/35055575. Nature. 2001. PMID: 11217863
Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats.
Kim YB, Peroni OD, Franke TF, Kahn BB. Kim YB, et al. Diabetes. 2000 May;49(5):847-56. doi: 10.2337/diabetes.49.5.847. Diabetes. 2000. PMID: 10905496
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