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A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity.
Khan S, Zhang X, Lv D, Zhang Q, He Y, Zhang P, Liu X, Thummuri D, Yuan Y, Wiegand JS, Pei J, Zhang W, Sharma A, McCurdy CR, Kuruvilla VM, Baran N, Ferrando AA, Kim YM, Rogojina A, Houghton PJ, Huang G, Hromas R, Konopleva M, Zheng G, Zhou D. Khan S, et al. Among authors: kim ym. Nat Med. 2019 Dec;25(12):1938-1947. doi: 10.1038/s41591-019-0668-z. Epub 2019 Dec 2. Nat Med. 2019. PMID: 31792461 Free PMC article.
BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition.
Duy C, Hurtz C, Shojaee S, Cerchietti L, Geng H, Swaminathan S, Klemm L, Kweon SM, Nahar R, Braig M, Park E, Kim YM, Hofmann WK, Herzog S, Jumaa H, Koeffler HP, Yu JJ, Heisterkamp N, Graeber TG, Wu H, Ye BH, Melnick A, Müschen M. Duy C, et al. Among authors: kim ym. Nature. 2011 May 19;473(7347):384-8. doi: 10.1038/nature09883. Nature. 2011. PMID: 21593872 Free PMC article.
Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition.
Saito K, Zhang Q, Yang H, Yamatani K, Ai T, Ruvolo V, Baran N, Cai T, Ma H, Jacamo R, Kuruvilla V, Imoto J, Kinjo S, Ikeo K, Moriya K, Suzuki K, Miida T, Kim YM, Vellano CP, Andreeff M, Marszalek JR, Tabe Y, Konopleva M. Saito K, et al. Among authors: kim ym. Blood Adv. 2021 Oct 26;5(20):4233-4255. doi: 10.1182/bloodadvances.2020003661. Blood Adv. 2021. PMID: 34507353 Free PMC article.
Editorial: Microenvironment and therapy-resistance in leukemias.
Friedmann R, Kim YM, Konopleva M. Friedmann R, et al. Among authors: kim ym. Front Oncol. 2023 Jul 14;13:1244642. doi: 10.3389/fonc.2023.1244642. eCollection 2023. Front Oncol. 2023. PMID: 37519784 Free PMC article. No abstract available.
Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells.
Aldana-Masangkay GI, Rodriguez-Gonzalez A, Lin T, Ikeda AK, Hsieh YT, Kim YM, Lomenick B, Okemoto K, Landaw EM, Wang D, Mazitschek R, Bradner JE, Sakamoto KM. Aldana-Masangkay GI, et al. Among authors: kim ym. Leuk Lymphoma. 2011 Aug;52(8):1544-55. doi: 10.3109/10428194.2011.570821. Epub 2011 Jun 23. Leuk Lymphoma. 2011. PMID: 21699378 Free PMC article.
BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia.
Hurtz C, Hatzi K, Cerchietti L, Braig M, Park E, Kim YM, Herzog S, Ramezani-Rad P, Jumaa H, Müller MC, Hofmann WK, Hochhaus A, Ye BH, Agarwal A, Druker BJ, Shah NP, Melnick AM, Müschen M. Hurtz C, et al. Among authors: kim ym. J Exp Med. 2011 Oct 24;208(11):2163-74. doi: 10.1084/jem.20110304. Epub 2011 Sep 12. J Exp Med. 2011. PMID: 21911423 Free PMC article.
Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function.
Trageser D, Iacobucci I, Nahar R, Duy C, von Levetzow G, Klemm L, Park E, Schuh W, Gruber T, Herzog S, Kim YM, Hofmann WK, Li A, Storlazzi CT, Jäck HM, Groffen J, Martinelli G, Heisterkamp N, Jumaa H, Müschen M. Trageser D, et al. Among authors: kim ym. J Exp Med. 2009 Aug 3;206(8):1739-53. doi: 10.1084/jem.20090004. Epub 2009 Jul 20. J Exp Med. 2009. PMID: 19620627 Free PMC article.
The Wnt signaling pathway in cancer.
Duchartre Y, Kim YM, Kahn M. Duchartre Y, et al. Among authors: kim ym. Crit Rev Oncol Hematol. 2016 Mar;99:141-9. doi: 10.1016/j.critrevonc.2015.12.005. Epub 2015 Dec 24. Crit Rev Oncol Hematol. 2016. PMID: 26775730 Free PMC article. Review.
3,972 results