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2020 6
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Urolithin A suppresses high glucose-induced neuronal amyloidogenesis by modulating TGM2-dependent ER-mitochondria contacts and calcium homeostasis.
Lee HJ, Jung YH, Choi GE, Kim JS, Chae CW, Lim JR, Kim SY, Yoon JH, Cho JH, Lee SJ, Han HJ. Lee HJ, et al. Cell Death Differ. 2021 Jan;28(1):184-202. doi: 10.1038/s41418-020-0593-1. Epub 2020 Jul 23. Cell Death Differ. 2021. PMID: 32704090 Free PMC article.
We also found that urolithin A or TGM2 silencing prevented Abeta-induced mitochondrial calcium influx, mtROS accumulation, Tau phosphorylation, and cell death in neuronal cells. In conclusion, we suggest that urolithin A is a promising candidate for the development …
We also found that urolithin A or TGM2 silencing prevented Abeta-induced mitochondrial calcium influx, mtROS accumulation, Tau phosphorylati …
CDK15 promotes colorectal cancer progression via phosphorylating PAK4 and regulating β-catenin/ MEK-ERK signaling pathway.
Huang C, Du R, Jia X, Liu K, Qiao Y, Wu Q, Yao N, Yang L, Zhou L, Liu X, Xiang P, Xin M, Wang Y, Chen X, Kim DJ, Dong Z, Li X. Huang C, et al. Cell Death Differ. 2022 Jan;29(1):14-27. doi: 10.1038/s41418-021-00828-6. Epub 2021 Jul 14. Cell Death Differ. 2022. PMID: 34262144 Free PMC article.
Here, we found that CDK15 was highly expressed in human CRC and negatively correlated with patient prognosis and overall survival in tissue microarray. Knockdown of CDK15 suppressed cell proliferation and anchorage-independent growth of CRC cells and inhibited tumor growth …
Here, we found that CDK15 was highly expressed in human CRC and negatively correlated with patient prognosis and overall survival in tissue …
Mitophagy protein PINK1 suppresses colon tumor growth by metabolic reprogramming via p53 activation and reducing acetyl-CoA production.
Yin K, Lee J, Liu Z, Kim H, Martin DR, Wu D, Liu M, Xue X. Yin K, et al. Cell Death Differ. 2021 Aug;28(8):2421-2435. doi: 10.1038/s41418-021-00760-9. Epub 2021 Mar 15. Cell Death Differ. 2021. PMID: 33723373 Free PMC article.
Interestingly, PINK1 overexpression in vivo increased apoptotic cell death and suppressed colon tumor xenograft growth. Metabolomic analysis revealed that acetyl-CoA was significantly reduced in tumors with PINK1 overexpression, which was partly due to activation of …
Interestingly, PINK1 overexpression in vivo increased apoptotic cell death and suppressed colon tumor xenograft growth. Metabo …
ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-kappaB.
Won M, Park KA, Kim S, Ju E, Ko Y, Yoo H, Ro H, Lee J, Oh J, Lee EG, Kim SY, Nam SW, Shen HM, Yeo MK, Kim JM, Hur GM. Won M, et al. Cell Death Differ. 2022 Jun;29(6):1152-1163. doi: 10.1038/s41418-021-00906-9. Epub 2021 Nov 27. Cell Death Differ. 2022. PMID: 34839354 Free PMC article.
In TNF signaling, ubiquitination of RIP1 functions as an early cell-death checkpoint, which prevents the spatial transition of the signaling complex from complex-I to death-inducing complex-II. ...Our work identifies ANKRD13a as a novel gatekeeper of the earl …
In TNF signaling, ubiquitination of RIP1 functions as an early cell-death checkpoint, which prevents the spatial transition of …
Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways.
Cho JH, Kim K, Kim SA, Park S, Park BO, Kim JH, Kim SY, Kwon MJ, Han MH, Lee SB, Park BC, Park SG, Kim JH, Kim S. Cho JH, et al. Cell Death Differ. 2021 Mar;28(3):900-914. doi: 10.1038/s41418-020-00649-z. Epub 2020 Oct 27. Cell Death Differ. 2021. PMID: 33110214 Free PMC article.
The mammalian Target of Rapamycin (mTOR) pathway regulates a variety of physiological processes, including cell growth and cancer progression. The regulatory mechanisms of these signals are extremely complex and comprise many feedback loops. ...Furthermore, OTUD5 knockdown …
The mammalian Target of Rapamycin (mTOR) pathway regulates a variety of physiological processes, including cell growth and cancer pro …
Modifiers of Somatic Repeat Instability in Mouse Models of Friedreich Ataxia and the Fragile X-Related Disorders: Implications for the Mechanism of Somatic Expansion in Huntington's Disease.
Zhao X, Kumari D, Miller CJ, Kim GY, Hayward B, Vitalo AG, Pinto RM, Usdin K. Zhao X, et al. J Huntingtons Dis. 2021;10(1):149-163. doi: 10.3233/JHD-200423. J Huntingtons Dis. 2021. PMID: 33579860 Free PMC article. Review.
In the case of HD, the expanded repeat unit is a CAG trinucleotide located in exon 1 of the huntingtin (HTT) gene, resulting in an expanded polyglutamine tract in the huntingtin protein. Expansion results in neuronal cell death, particularly in the striatum. Emergin …
In the case of HD, the expanded repeat unit is a CAG trinucleotide located in exon 1 of the huntingtin (HTT) gene, resulting in an expanded …
Programmed Cell Death-Ligand 1 (PD-L1) gene Single Nucleotide Polymorphism in Graves' Disease and Hashimoto's Thyroiditis in Korean Patients.
Yoon JH, Shin MH, Kim HN, Choi W, Park JY, Hong AR, Kim HK, Kang HC. Yoon JH, et al. Endocrinol Metab (Seoul). 2021 Jun;36(3):599-606. doi: 10.3803/EnM.2021.965. Epub 2021 Jun 2. Endocrinol Metab (Seoul). 2021. PMID: 34074094 Free PMC article.
BACKGROUND: Programmed cell death-ligand 1 (PD-L1) has an important role in regulating immune reactions by binding to programmed death 1 (PD-1) on immune cells, which could prevent the exacerbation of autoimmune thyroid disease (AITD). ...RESULTS: Genotype fr …
BACKGROUND: Programmed cell death-ligand 1 (PD-L1) has an important role in regulating immune reactions by binding to programm …
Relationship of the lung microbiome with PD-L1 expression and immunotherapy response in lung cancer.
Jang HJ, Choi JY, Kim K, Yong SH, Kim YW, Kim SY, Kim EY, Jung JY, Kang YA, Park MS, Kim YS, Cho YJ, Lee SH. Jang HJ, et al. Respir Res. 2021 Dec 28;22(1):322. doi: 10.1186/s12931-021-01919-1. Respir Res. 2021. PMID: 34963470 Free PMC article.
Patients were stratified based on programmed death-ligand 1 (PD-L1) expression levels and immunotherapy responses. RESULTS: In total, 84 patients were prospectively analyzed, of which 59 showed low (< 10%), and 25 showed high ( 10%) PD-L1 expression levels. The alpha an …
Patients were stratified based on programmed death-ligand 1 (PD-L1) expression levels and immunotherapy responses. RESULTS: In total, …
Developmentally regulated GTP-binding protein 2 levels in prostate cancer cell lines impact docetaxel-induced apoptosis.
Kim SC, Lee WH, Kim SH, Abdulkhayevich AA, Park JW, Kim YM, Moon KH, Lee SH, Park S. Kim SC, et al. Investig Clin Urol. 2021 Jul;62(4):485-495. doi: 10.4111/icu.20200574. Investig Clin Urol. 2021. PMID: 34190439 Free PMC article.
PURPOSE: This study aimed to confirm the association between developmentally regulated GTP-binding protein 2 (DRG2) expression and docetaxel-induced apoptosis and to determine whether prostate cancer responses to docetaxel treatment differ with DRG2 expression. MATERIALS A …
PURPOSE: This study aimed to confirm the association between developmentally regulated GTP-binding protein 2 (DRG2) expression and docetaxel …
28 results