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2020 6
2021 27
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Urolithin A suppresses high glucose-induced neuronal amyloidogenesis by modulating TGM2-dependent ER-mitochondria contacts and calcium homeostasis.
Lee HJ, Jung YH, Choi GE, Kim JS, Chae CW, Lim JR, Kim SY, Yoon JH, Cho JH, Lee SJ, Han HJ. Lee HJ, et al. Cell Death Differ. 2021 Jan;28(1):184-202. doi: 10.1038/s41418-020-0593-1. Epub 2020 Jul 23. Cell Death Differ. 2021. PMID: 32704090 Free PMC article.
We also found that urolithin A or TGM2 silencing prevented Abeta-induced mitochondrial calcium influx, mtROS accumulation, Tau phosphorylation, and cell death in neuronal cells. In conclusion, we suggest that urolithin A is a promising candidate for the development …
We also found that urolithin A or TGM2 silencing prevented Abeta-induced mitochondrial calcium influx, mtROS accumulation, Tau phosphorylati …
Mitophagy protein PINK1 suppresses colon tumor growth by metabolic reprogramming via p53 activation and reducing acetyl-CoA production.
Yin K, Lee J, Liu Z, Kim H, Martin DR, Wu D, Liu M, Xue X. Yin K, et al. Cell Death Differ. 2021 Aug;28(8):2421-2435. doi: 10.1038/s41418-021-00760-9. Epub 2021 Mar 15. Cell Death Differ. 2021. PMID: 33723373 Free PMC article.
Interestingly, PINK1 overexpression in vivo increased apoptotic cell death and suppressed colon tumor xenograft growth. Metabolomic analysis revealed that acetyl-CoA was significantly reduced in tumors with PINK1 overexpression, which was partly due to activation of …
Interestingly, PINK1 overexpression in vivo increased apoptotic cell death and suppressed colon tumor xenograft growth. Metabo …
ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-kappaB.
Won M, Park KA, Kim S, Ju E, Ko Y, Yoo H, Ro H, Lee J, Oh J, Lee EG, Kim SY, Nam SW, Shen HM, Yeo MK, Kim JM, Hur GM. Won M, et al. Cell Death Differ. 2022 Jun;29(6):1152-1163. doi: 10.1038/s41418-021-00906-9. Epub 2021 Nov 27. Cell Death Differ. 2022. PMID: 34839354 Free PMC article.
In TNF signaling, ubiquitination of RIP1 functions as an early cell-death checkpoint, which prevents the spatial transition of the signaling complex from complex-I to death-inducing complex-II. ...Our work identifies ANKRD13a as a novel gatekeeper of the earl …
In TNF signaling, ubiquitination of RIP1 functions as an early cell-death checkpoint, which prevents the spatial transition of …
Programmed Cell Death-Ligand 1 (PD-L1) gene Single Nucleotide Polymorphism in Graves' Disease and Hashimoto's Thyroiditis in Korean Patients.
Yoon JH, Shin MH, Kim HN, Choi W, Park JY, Hong AR, Kim HK, Kang HC. Yoon JH, et al. Endocrinol Metab (Seoul). 2021 Jun;36(3):599-606. doi: 10.3803/EnM.2021.965. Epub 2021 Jun 2. Endocrinol Metab (Seoul). 2021. PMID: 34074094 Free PMC article.
BACKGROUND: Programmed cell death-ligand 1 (PD-L1) has an important role in regulating immune reactions by binding to programmed death 1 (PD-1) on immune cells, which could prevent the exacerbation of autoimmune thyroid disease (AITD). ...RESULTS: Genotype fr …
BACKGROUND: Programmed cell death-ligand 1 (PD-L1) has an important role in regulating immune reactions by binding to programm …
Modifiers of Somatic Repeat Instability in Mouse Models of Friedreich Ataxia and the Fragile X-Related Disorders: Implications for the Mechanism of Somatic Expansion in Huntington's Disease.
Zhao X, Kumari D, Miller CJ, Kim GY, Hayward B, Vitalo AG, Pinto RM, Usdin K. Zhao X, et al. J Huntingtons Dis. 2021;10(1):149-163. doi: 10.3233/JHD-200423. J Huntingtons Dis. 2021. PMID: 33579860 Free PMC article. Review.
In the case of HD, the expanded repeat unit is a CAG trinucleotide located in exon 1 of the huntingtin (HTT) gene, resulting in an expanded polyglutamine tract in the huntingtin protein. Expansion results in neuronal cell death, particularly in the striatum. Emergin …
In the case of HD, the expanded repeat unit is a CAG trinucleotide located in exon 1 of the huntingtin (HTT) gene, resulting in an expanded …
Aggressive behaviour of Hodgkin's-like lymphoma in a domestic ferret.
Kim HS, Kim HJ, Hwang HJ, Oh S, Do SH. Kim HS, et al. Vet Med (Praha). 2021 May 3;66(5):225-232. doi: 10.17221/115/2020-VETMED. eCollection 2021 May. Vet Med (Praha). 2021. PMID: 40201856 Free PMC article.
Immunohistochemically, most neoplastic cells were positive for vimentin and BLA-36, weakly positive for CD20, and negative for Pax5, CD79a, CD3, CD45, and Iba-1, demonstrating similarity to human Hodgkin's lymphoma (HL). In addition, a prominent programmed cell death …
Immunohistochemically, most neoplastic cells were positive for vimentin and BLA-36, weakly positive for CD20, and negative for Pax5, CD79a, …
Ssu72-HNF4α signaling axis classify the transition from steatohepatitis to hepatocellular carcinoma.
Kim HS, Yoon JS, Jeon Y, Park EJ, Lee JK, Chen S, Lee H, Park JY, Go H, Lee CW. Kim HS, et al. Cell Death Differ. 2022 Mar;29(3):600-613. doi: 10.1038/s41418-021-00877-x. Epub 2021 Oct 6. Cell Death Differ. 2022. PMID: 34616001 Free PMC article.
Importantly, hepatic Ssu72 loss resulted in the induction of mature hepatocyte-to-progenitor cell conversion, by dedifferentiation orchestrated by Ssu72-mediated hypo-phosphorylation of hepatocyte nuclear factor 4alpha (HNF4alpha), a master regulator of hepatocyte function …
Importantly, hepatic Ssu72 loss resulted in the induction of mature hepatocyte-to-progenitor cell conversion, by dedifferentiation or …
Developmentally regulated GTP-binding protein 2 levels in prostate cancer cell lines impact docetaxel-induced apoptosis.
Kim SC, Lee WH, Kim SH, Abdulkhayevich AA, Park JW, Kim YM, Moon KH, Lee SH, Park S. Kim SC, et al. Investig Clin Urol. 2021 Jul;62(4):485-495. doi: 10.4111/icu.20200574. Investig Clin Urol. 2021. PMID: 34190439 Free PMC article.
PURPOSE: This study aimed to confirm the association between developmentally regulated GTP-binding protein 2 (DRG2) expression and docetaxel-induced apoptosis and to determine whether prostate cancer responses to docetaxel treatment differ with DRG2 expression. MATERIALS A …
PURPOSE: This study aimed to confirm the association between developmentally regulated GTP-binding protein 2 (DRG2) expression and docetaxel …
LIN28A enhances regenerative capacity of human somatic tissue stem cells via metabolic and mitochondrial reprogramming.
Pieknell K, Sulistio YA, Wulansari N, Darsono WHW, Chang MY, Ko JY, Chang JW, Kim MJ, Lee MR, Lee SA, Lee H, Lee G, Jung BH, Park H, Kim GH, Kim D, Cho G, Kim CH, Ly DD, Park KS, Lee SH. Pieknell K, et al. Cell Death Differ. 2022 Mar;29(3):540-555. doi: 10.1038/s41418-021-00873-1. Epub 2021 Sep 23. Cell Death Differ. 2022. PMID: 34556809 Free PMC article.
The reprogramming allows SSCs to undergo cell proliferation more extensively with low levels of oxidative and mitochondrial stress. ...
The reprogramming allows SSCs to undergo cell proliferation more extensively with low levels of oxidative and mitochondrial stress. . …
28 results