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Self-eating and self-killing: crosstalk between autophagy and apoptosis.
Maiuri MC, Zalckvar E, Kimchi A, Kroemer G. Maiuri MC, et al. Nat Rev Mol Cell Biol. 2007 Sep;8(9):741-52. doi: 10.1038/nrm2239. Nat Rev Mol Cell Biol. 2007. PMID: 17717517 Review.
Autophagy and apoptosis may be triggered by common upstream signals, and sometimes this results in combined autophagy and apoptosis; in other instances, the cell switches between the two responses in a mutually exclusive manner. On a molecular level, this means that …
Autophagy and apoptosis may be triggered by common upstream signals, and sometimes this results in combined autophagy and apoptosis; in othe …
A systems level strategy for analyzing the cell death network: implication in exploring the apoptosis/autophagy connection.
Zalckvar E, Yosef N, Reef S, Ber Y, Rubinstein AD, Mor I, Sharan R, Ruppin E, Kimchi A. Zalckvar E, et al. Cell Death Differ. 2010 Aug;17(8):1244-53. doi: 10.1038/cdd.2010.7. Epub 2010 Feb 12. Cell Death Differ. 2010. PMID: 20150916
Here, we developed a platform that is based on single and double sets of RNAi-mediated perturbations targeting combinations of apoptotic and autophagic genes. ...The knock down of caspase3 turned on a switch toward autophagic cell death, which requires Atg5 or Becli …
Here, we developed a platform that is based on single and double sets of RNAi-mediated perturbations targeting combinations of apopto …
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.
Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnóczky G, Hardwick JM, Hengartner MO, Ichijo H, Jäättelä M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malomi W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nuñez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G. Galluzzi L, et al. Cell Death Differ. 2009 Aug;16(8):1093-107. doi: 10.1038/cdd.2009.44. Epub 2009 Apr 17. Cell Death Differ. 2009. PMID: 19373242 Free PMC article. Review.
Cell death is essential for a plethora of physiological processes, and its deregulation characterizes numerous human diseases. ...Here, we provide a nonexhaustive comparison of methods to detect cell death with apoptotic or nonapoptotic morphologies, their advantage …
Cell death is essential for a plethora of physiological processes, and its deregulation characterizes numerous human diseases. ...Her …
Life and death partners: apoptosis, autophagy and the cross-talk between them.
Eisenberg-Lerner A, Bialik S, Simon HU, Kimchi A. Eisenberg-Lerner A, et al. Cell Death Differ. 2009 Jul;16(7):966-75. doi: 10.1038/cdd.2009.33. Epub 2009 Mar 27. Cell Death Differ. 2009. PMID: 19325568 Review.
It is not surprising that the demise of a cell is a complex well-controlled process. Apoptosis, the first genetically programmed death process identified, has been extensively studied and its contribution to the pathogenesis of disease well documented. Yet, apoptosi …
It is not surprising that the demise of a cell is a complex well-controlled process. Apoptosis, the first genetically programm …
Changes in cIAP2, survivin and BimEL expression characterize the switch from autophagy to apoptosis in prolonged starvation.
Hay-Koren A, Bialik S, Levin-Salomon V, Kimchi A. Hay-Koren A, et al. J Intern Med. 2017 May;281(5):458-470. doi: 10.1111/joim.12616. J Intern Med. 2017. PMID: 28425584
This process is a survival mechanism, enabling cells to cope with nutrient deprivation by degradation and recycling of macromolecules. ...The transition to apoptosis correlated with a selective decline in the mRNA and protein levels of two anti-apoptotic IAP family …
This process is a survival mechanism, enabling cells to cope with nutrient deprivation by degradation and recycling of macromolecules …
DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation.
Raveh T, Droguett G, Horwitz MS, DePinho RA, Kimchi A. Raveh T, et al. Nat Cell Biol. 2001 Jan;3(1):1-7. doi: 10.1038/35050500. Nat Cell Biol. 2001. PMID: 11146619
DAP kinase is a pro-apoptotic calcium-regulated serine/threonine kinase, whose expression is frequently lost in human tumours. Here we show that DAP kinase counteracts oncogene-induced transformation by activating a p19ARF/p53-dependent apoptotic checkpoint. ...
DAP kinase is a pro-apoptotic calcium-regulated serine/threonine kinase, whose expression is frequently lost in human tumours. Here w …
DAP-kinase participates in TNF-alpha- and Fas-induced apoptosis and its function requires the death domain.
Cohen O, Inbal B, Kissil JL, Raveh T, Berissi H, Spivak-Kroizaman T, Feinstein E, Kimchi A. Cohen O, et al. J Cell Biol. 1999 Jul 12;146(1):141-8. doi: 10.1083/jcb.146.1.141. J Cell Biol. 1999. PMID: 10402466 Free PMC article.
Death-associated protein (DAP)-kinase is a calcium/calmodulin regulated serine/threonine kinase that carries ankyrin repeats, a death domain, and is localized to the cytoskeleton. ...Overexpression of a fragment encompassing the death domain of DAP-kinase act …
Death-associated protein (DAP)-kinase is a calcium/calmodulin regulated serine/threonine kinase that carries ankyrin repeats, a
Autophagy and tumor suppression: recent advances in understanding the link between autophagic cell death pathways and tumor development.
Bialik S, Kimchi A. Bialik S, et al. Adv Exp Med Biol. 2008;615:177-200. doi: 10.1007/978-1-4020-6554-5_9. Adv Exp Med Biol. 2008. PMID: 18437896 Review.
Autophagy is a process by which the cell recycles its components through self-consumption of cellular organelles and bulk cytoplasm. ...We conclude with a survey of recent approaches to treating cancer with strategies that modulate autophagy....
Autophagy is a process by which the cell recycles its components through self-consumption of cellular organelles and bulk cytoplasm. …
The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase.
Guenebeaud C, Goldschneider D, Castets M, Guix C, Chazot G, Delloye-Bourgeois C, Eisenberg-Lerner A, Shohat G, Zhang M, Laudet V, Kimchi A, Bernet A, Mehlen P. Guenebeaud C, et al. Mol Cell. 2010 Dec 22;40(6):863-76. doi: 10.1016/j.molcel.2010.11.021. Mol Cell. 2010. PMID: 21172653
While performing a siRNA screen to identify genes implicated in UNC5H-induced apoptosis, we identified the structural subunit PR65β of the holoenzyme protein phosphatase 2A (PP2A). ...Thus we show here that, in the absence of netrin-1, recruitment of PP2A to UNC5H2/B allow …
While performing a siRNA screen to identify genes implicated in UNC5H-induced apoptosis, we identified the structural subunit PR65β o …
Life in the balance - a mechanistic view of the crosstalk between autophagy and apoptosis.
Rubinstein AD, Kimchi A. Rubinstein AD, et al. J Cell Sci. 2012 Nov 15;125(Pt 22):5259-68. doi: 10.1242/jcs.115865. J Cell Sci. 2012. PMID: 23377657 Review.
The physiological relevance of the autophagy-apoptosis crosstalk is not well understood, but it is presumed to facilitate a controlled and well-balanced cellular response to a given stress signal. ...In a third paradigm unique to autophagy, caspases are recru …
The physiological relevance of the autophagy-apoptosis crosstalk is not well understood, but it is presumed to facilitate a controlle …
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