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Discovery of Clinical Candidate AZD5462, a Selective Oral Allosteric RXFP1 Agonist for Treatment of Heart Failure.
Granberg KL, Sakamaki S, Larsson N, Bergström F, Fuchigami R, Niwa Y, Ryberg E, Backmark A, Kato H, Miyazaki S, Iguchi K, Sakamoto T, Persson M, Idei A, Prieto Garcia L, Villar IC, Gradén H, Bergonzini G, Arvidsson T, Fujita T, Althage M, Ulander J, Kimura J, Yoneda H, Fjellström O, Mochida H, Lal M. Granberg KL, et al. Among authors: kimura j. J Med Chem. 2024 Mar 28;67(6):4419-4441. doi: 10.1021/acs.jmedchem.3c02184. Epub 2024 Mar 19. J Med Chem. 2024. PMID: 38502782
Identification of Novel Series of Potent and Selective Relaxin Family Peptide Receptor 1 (RXFP1) Agonists.
Granberg KL, Sakamaki S, Fuchigami R, Niwa Y, Fujio M, Kato H, Bergström F, Larsson N, Persson M, Villar IC, Fujita T, Sugikawa E, Althage M, Yano N, Yokoyama Y, Kimura J, Lal M, Mochida H. Granberg KL, et al. Among authors: kimura j. J Med Chem. 2024 Mar 28;67(6):4442-4462. doi: 10.1021/acs.jmedchem.3c02183. Epub 2024 Mar 19. J Med Chem. 2024. PMID: 38502780
1,252 results