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Did you mean kanamycin analog (2,329 results)?
Kinamycins A and C, bacterial metabolites that contain an unusual diazo group, as potential new anticancer agents: antiproliferative and cell cycle effects.
Hasinoff BB, Wu X, Yalowich JC, Goodfellow V, Laufer RS, Adedayo O, Dmitrienko GI. Hasinoff BB, et al. Anticancer Drugs. 2006 Aug;17(7):825-37. doi: 10.1097/01.cad.0000224442.78211.27. Anticancer Drugs. 2006. PMID: 16926632
The cell growth and cell cycle inhibitory properties of the bacterial metabolites kinamycin A and kinamycin C were investigated in an attempt to determine their mechanism of action and to develop these or their analogs as anticancer agents. ...Both kinamyc
The cell growth and cell cycle inhibitory properties of the bacterial metabolites kinamycin A and kinamycin C were investigate …
Offloading Role of a Discrete Thioesterase in Type II Polyketide Biosynthesis.
Hua K, Liu X, Zhao Y, Gao Y, Pan L, Zhang H, Deng Z, Jiang M. Hua K, et al. mBio. 2020 Sep 15;11(5):e01334-20. doi: 10.1128/mBio.01334-20. mBio. 2020. PMID: 32934080 Free PMC article.
Despite its critical role in type II polyketide biosynthesis, the enzyme and its corresponding mechanism for type II polyketide chain release through thioester bond breakage have yet to be determined. Here, kinamycin was used as a model compound to investigate the chain re …
Despite its critical role in type II polyketide biosynthesis, the enzyme and its corresponding mechanism for type II polyketide chain releas …
A83016A, a new kinamycin type antibiotic.
Smitka TA, Bonjouklian R, Perun TJ Jr, Hunt AH, Foster RS, Mynderse JS, Yao RC. Smitka TA, et al. J Antibiot (Tokyo). 1992 Apr;45(4):581-3. doi: 10.7164/antibiotics.45.581. J Antibiot (Tokyo). 1992. PMID: 1592690 Free article. No abstract available.
A single Sfp-type phosphopantetheinyl transferase plays a major role in the biosynthesis of PKS and NRPS derived metabolites in Streptomyces ambofaciens ATCC23877.
Bunet R, Riclea R, Laureti L, Hôtel L, Paris C, Girardet JM, Spiteller D, Dickschat JS, Leblond P, Aigle B. Bunet R, et al. PLoS One. 2014 Jan 31;9(1):e87607. doi: 10.1371/journal.pone.0087607. eCollection 2014. PLoS One. 2014. PMID: 24498152 Free PMC article.
Two other PPTase genes, samT0172 (alpN) and samL0372, are located within a type II PKS gene cluster responsible for the kinamycin production and an hybrid NRPS-PKS cluster involved in antimycin production, respectively, and their products were shown to be specifically invo …
Two other PPTase genes, samT0172 (alpN) and samL0372, are located within a type II PKS gene cluster responsible for the kinamycin pro …
Mimicking the biological activity of diazobenzo[b]fluorene natural products with electronically tuned diazofluorene analogs.
Zeng W, Eric Ballard T, Tkachenko AG, Burns VA, Feldheim DL, Melander C. Zeng W, et al. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5148-51. doi: 10.1016/j.bmcl.2006.07.024. Epub 2006 Jul 25. Bioorg Med Chem Lett. 2006. PMID: 16870443
Under appropriate electronic modulation, simple diazofluorene analogs recapitulate the DNA cleavage activity of kinamycin D under thiol-based reducing conditions. ...
Under appropriate electronic modulation, simple diazofluorene analogs recapitulate the DNA cleavage activity of kinamycin D un …