Offloading Role of a Discrete Thioesterase in Type II Polyketide Biosynthesis.
Hua K, Liu X, Zhao Y, Gao Y, Pan L, Zhang H, Deng Z, Jiang M.
Hua K, et al.
mBio. 2020 Sep 15;11(5):e01334-20. doi: 10.1128/mBio.01334-20.
mBio. 2020.
PMID: 32934080
Free PMC article.
Despite its critical role in type II polyketide biosynthesis, the enzyme and its corresponding mechanism for type II polyketide chain release through thioester bond breakage have yet to be determined. Here, kinamycin was used as a model compound to investigate the chain re …
Despite its critical role in type II polyketide biosynthesis, the enzyme and its corresponding mechanism for type II polyketide chain releas …