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Eukaryotic domain of unknown function DUF738 belongs to Gcn5-related N-acetyltransferase superfamily.
Steczkiewicz K, Kinch L, Grishin NV, Rychlewski L, Ginalski K. Steczkiewicz K, et al. Among authors: kinch l. Cell Cycle. 2006 Dec;5(24):2927-30. doi: 10.4161/cc.5.24.3572. Epub 2006 Dec 15. Cell Cycle. 2006. PMID: 17172875 No abstract available.
Hyperactivation of TORC1 Drives Resistance to the Pan-HER Tyrosine Kinase Inhibitor Neratinib in HER2-Mutant Cancers.
Sudhan DR, Guerrero-Zotano A, Won H, González Ericsson P, Servetto A, Huerta-Rosario M, Ye D, Lee KM, Formisano L, Guo Y, Liu Q, Kinch LN, Red Brewer M, Dugger T, Koch J, Wick MJ, Cutler RE Jr, Lalani AS, Bryce R, Auerbach A, Hanker AB, Arteaga CL. Sudhan DR, et al. Among authors: kinch ln. Cancer Cell. 2020 Feb 10;37(2):183-199.e5. doi: 10.1016/j.ccell.2019.12.013. Epub 2020 Jan 23. Cancer Cell. 2020. PMID: 31978326
A lytic polysaccharide monooxygenase-like protein functions in fungal copper import and meningitis.
Garcia-Santamarina S, Probst C, Festa RA, Ding C, Smith AD, Conklin SE, Brander S, Kinch LN, Grishin NV, Franz KJ, Riggs-Gelasco P, Lo Leggio L, Johansen KS, Thiele DJ. Garcia-Santamarina S, et al. Among authors: kinch ln. Nat Chem Biol. 2020 Mar;16(3):337-344. doi: 10.1038/s41589-019-0437-9. Epub 2020 Jan 13. Nat Chem Biol. 2020. PMID: 31932719 Free PMC article.
Functional analysis of Rossmann-like domains reveals convergent evolution of topology and reaction pathways.
Medvedev KE, Kinch LN, Schaeffer RD, Grishin NV. Medvedev KE, et al. PLoS Comput Biol. 2019 Dec 23;15(12):e1007569. doi: 10.1371/journal.pcbi.1007569. eCollection 2019 Dec. PLoS Comput Biol. 2019. PMID: 31869345 Free PMC article.
Recent advances suggest increased influence of selective pressure in allostery.
Bhat AS, Dustin Schaeffer R, Kinch L, Medvedev KE, Grishin NV. Bhat AS, et al. Among authors: kinch l. Curr Opin Struct Biol. 2020 Jun;62:183-188. doi: 10.1016/j.sbi.2020.02.004. Epub 2020 Apr 14. Curr Opin Struct Biol. 2020. PMID: 32302874 Review.
Mutation severity spectrum of rare alleles in the human genome is predictive of disease type.
Pei J, Kinch LN, Otwinowski Z, Grishin NV. Pei J, et al. Among authors: kinch ln. PLoS Comput Biol. 2020 May 15;16(5):e1007775. doi: 10.1371/journal.pcbi.1007775. eCollection 2020 May. PLoS Comput Biol. 2020. PMID: 32413045 Free PMC article.
╬▓-Strand-mediated interactions of protein domains.
Bhat AS, Kinch LN, Grishin NV. Bhat AS, et al. Among authors: kinch ln. Proteins. 2020 Nov;88(11):1513-1527. doi: 10.1002/prot.25970. Epub 2020 Jul 11. Proteins. 2020. PMID: 32543729
A Fifth of the Protein World: Rossmann-like Proteins as an Evolutionarily Successful Structural unit.
Medvedev KE, Kinch LN, Dustin Schaeffer R, Pei J, Grishin NV. Medvedev KE, et al. Among authors: kinch ln. J Mol Biol. 2020 Dec 31;433(4):166788. doi: 10.1016/j.jmb.2020.166788. Online ahead of print. J Mol Biol. 2020. PMID: 33387532
RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer.
Yenerall P, Das AK, Wang S, Kollipara RK, Li LS, Villalobos P, Flaming J, Lin YF, Huffman K, Timmons BC, Gilbreath C, Sonavane R, Kinch LN, Rodriguez-Canales J, Moran C, Behrens C, Hirasawa M, Takata T, Murakami R, Iwanaga K, Chen BPC, Grishin NV, Raj GV, Wistuba II, Minna JD, Kittler R. Yenerall P, et al. Cell Chem Biol. 2020 Jan 16;27(1):105-121.e14. doi: 10.1016/j.chembiol.2019.12.005. Epub 2019 Dec 26. Cell Chem Biol. 2020. PMID: 31883965
Structure, lipid scrambling activity and role in autophagosome formation of ATG9A.
Maeda S, Yamamoto H, Kinch LN, Garza CM, Takahashi S, Otomo C, Grishin NV, Forli S, Mizushima N, Otomo T. Maeda S, et al. Among authors: kinch ln. Nat Struct Mol Biol. 2020 Dec;27(12):1194-1201. doi: 10.1038/s41594-020-00520-2. Epub 2020 Oct 26. Nat Struct Mol Biol. 2020. PMID: 33106659
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