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Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis.
Damsky W, Wang A, Kim DJ, Young BD, Singh K, Murphy MJ, Daccache J, Clark A, Ayasun R, Ryu C, McGeary MK, Odell ID, Fazzone-Chettiar R, Pucar D, Homer R, Gulati M, Miller EJ, Bosenberg M, Flavell RA, King B. Damsky W, et al. Among authors: king b. Nat Commun. 2022 Jun 6;13(1):3140. doi: 10.1038/s41467-022-30615-x. Nat Commun. 2022. PMID: 35668129 Free PMC article. Clinical Trial.
Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets.
Golec E, Ekström A, Noga M, Omar-Hmeadi M, Lund PE, Villoutreix BO, Krus U, Wozniak K, Korsgren O, Renström E, Barg S, King BC, Blom AM. Golec E, et al. Among authors: king bc. Proc Natl Acad Sci U S A. 2022 Jun 14;119(24):e2120083119. doi: 10.1073/pnas.2120083119. Epub 2022 Jun 6. Proc Natl Acad Sci U S A. 2022. PMID: 35666870 Free PMC article.
2,732 results