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Mucosal immunization with polyamine transport protein D (PotD) protects mice against nasopharyngeal colonization with Streptococcus pneumoniae.
Shah P, Briles DE, King J, Hale Y, Swiatlo E. Shah P, et al. Exp Biol Med (Maywood). 2009 Apr;234(4):403-9. doi: 10.3181/0809-RM-269. Epub 2009 Jan 28. Exp Biol Med (Maywood). 2009. PMID: 19176871
Secretory-IgA antibodies play an important role in the immunity to Streptococcus pneumoniae.
Fukuyama Y, King JD, Kataoka K, Kobayashi R, Gilbert RS, Oishi K, Hollingshead SK, Briles DE, Fujihashi K. Fukuyama Y, et al. J Immunol. 2010 Aug 1;185(3):1755-62. doi: 10.4049/jimmunol.1000831. Epub 2010 Jun 28. J Immunol. 2010. PMID: 20585031
A combination of Flt3 ligand cDNA and CpG oligodeoxynucleotide as nasal adjuvant elicits protective secretory-IgA immunity to Streptococcus pneumoniae in aged mice.
Fukuyama Y, King JD, Kataoka K, Kobayashi R, Gilbert RS, Hollingshead SK, Briles DE, Fujihashi K. Fukuyama Y, et al. J Immunol. 2011 Feb 15;186(4):2454-61. doi: 10.4049/jimmunol.1002837. Epub 2011 Jan 17. J Immunol. 2011. PMID: 21242514
Competition among Streptococcus pneumoniae for intranasal colonization in a mouse model.
Lipsitch M, Dykes JK, Johnson SE, Ades EW, King J, Briles DE, Carlone GM. Lipsitch M, et al. Vaccine. 2000 Jun 15;18(25):2895-901. doi: 10.1016/s0264-410x(00)00046-3. Vaccine. 2000. PMID: 10812233
The potential to use PspA and other pneumococcal proteins to elicit protection against pneumococcal infection.
Briles DE, Hollingshead S, Brooks-Walter A, Nabors GS, Ferguson L, Schilling M, Gravenstein S, Braun P, King J, Swift A. Briles DE, et al. Vaccine. 2000 Feb 25;18(16):1707-11. doi: 10.1016/s0264-410x(99)00511-3. Vaccine. 2000. PMID: 10689153 Clinical Trial.
The proline-rich region of pneumococcal surface proteins A and C contains surface-accessible epitopes common to all pneumococci and elicits antibody-mediated protection against sepsis.
Daniels CC, Coan P, King J, Hale J, Benton KA, Briles DE, Hollingshead SK. Daniels CC, et al. Infect Immun. 2010 May;78(5):2163-72. doi: 10.1128/IAI.01199-09. Epub 2010 Mar 1. Infect Immun. 2010. PMID: 20194601 Free PMC article.
Pneumococcal surface protein A is expressed in vivo, and antibodies to PspA are effective for therapy in a murine model of pneumococcal sepsis.
Swiatlo E, King J, Nabors GS, Mathews B, Briles DE. Swiatlo E, et al. Infect Immun. 2003 Dec;71(12):7149-53. doi: 10.1128/iai.71.12.7149-7153.2003. Infect Immun. 2003. PMID: 14638806 Free PMC article.
Natural materno-fetal transfer of antibodies to PspA and to PsaA.
Baril L, Briles DE, Crozier P, King JD, Hollingshead SK, Murphy TF, McCormick JB. Baril L, et al. Clin Exp Immunol. 2004 Mar;135(3):474-7. doi: 10.1111/j.1365-2249.2003.02357.x. Clin Exp Immunol. 2004. PMID: 15008981 Free PMC article.
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