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Injection of Cultured Cells with a ROCK Inhibitor for Bullous Keratopathy.
Kinoshita S, Koizumi N, Ueno M, Okumura N, Imai K, Tanaka H, Yamamoto Y, Nakamura T, Inatomi T, Bush J, Toda M, Hagiya M, Yokota I, Teramukai S, Sotozono C, Hamuro J. Kinoshita S, et al. N Engl J Med. 2018 Mar 15;378(11):995-1003. doi: 10.1056/NEJMoa1712770. N Engl J Med. 2018. PMID: 29539291 Clinical Trial.
BACKGROUND: Corneal endothelial cell (CEC) disorders, such as Fuchs's endothelial corneal dystrophy, induce abnormal corneal hydration and result in corneal haziness and vision loss known as bullous keratopathy. ...
BACKGROUND: Corneal endothelial cell (CEC) disorders, such as Fuchs's endothelial corneal dystrophy, induce abnormal corneal hydratio …
Keratinocyte growth factor accelerates corneal epithelial wound healing in vivo.
Sotozono C, Inatomi T, Nakamura M, Kinoshita S. Sotozono C, et al. Among authors: Kinoshita S. Invest Ophthalmol Vis Sci. 1995 Jul;36(8):1524-9. Invest Ophthalmol Vis Sci. 1995. PMID: 7601632
In addition, the distribution of S-phase cells in KGF-treated and control corneas was investigated during regeneration and under normal conditions. ...In the S-phase cell analysis, KGF did not have any effect on normal corneal epithelial cells. However, in the regenerating cornea, the number of S-phase cells in the KGF-treated limbal epithelium was twofold higher than in the controls. ...
In addition, the distribution of S-phase cells in KGF-treated and control corneas was investigated during regeneration and under norm …
Ocular surface abnormalities in aniridia.
Nishida K, Kinoshita S, Ohashi Y, Kuwayama Y, Yamamoto S. Nishida K, et al. Among authors: Kinoshita S. Am J Ophthalmol. 1995 Sep;120(3):368-75. doi: 10.1016/s0002-9394(14)72167-1. Am J Ophthalmol. 1995. PMID: 7661209
Enhancement of growth of rabbit corneal endothelial cells by PDGF.
Kamiyama K, Iguchi I, Wang X, Kita M, Imanishi J, Yamaguchi N, Hongo M, Sotozono C, Kinoshita S. Kamiyama K, et al. Among authors: Kinoshita S. Cornea. 1995 Mar;14(2):187-95. Cornea. 1995. PMID: 7743803
[Transforming growth factor-beta (TGF-beta) inhibits epithelial wound healing of organ-cultured rabbit cornea].
Nishida K, Ohashi Y, Nezu E, Yamamoto S, Kinoshita S, Fujita K. Nishida K, et al. Among authors: Kinoshita S. Nippon Ganka Gakkai Zasshi. 1993 Aug;97(8):899-905. Nippon Ganka Gakkai Zasshi. 1993. PMID: 8368177 Japanese.
TGF-beta at 1 ng/ml and 10 ng/ml concentrations showed significant decrease in wound-healing rate compared with the control. 5-bromo-2'-deoxyuridine-immunohistochemistry showed a significant decrease in S-phase cell count in the 1 ng/ml group compared with the control. ...
TGF-beta at 1 ng/ml and 10 ng/ml concentrations showed significant decrease in wound-healing rate compared with the control. 5-bromo-2'-deox …
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