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Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis.

Ferraiuolo L, Kirby J, Grierson AJ, Sendtner M, Shaw PJ. Ferraiuolo L, et al. Among authors: kirby j. Nat Rev Neurol. 2011 Nov;7(11):616-30. doi: 10.1038/nrneurol.2011.152. Nat Rev Neurol. 2011. PMID: 22051914 Review.

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Differential gene expression in a cell culture model of SOD1-related familial motor neurone disease.

Kirby J, Menzies FM, Cookson MR, Bushby K, Shaw PJ. Kirby J, et al. Hum Mol Genet. 2002 Aug 15;11(17):2061-75. doi: 10.1093/hmg/11.17.2061. Hum Mol Genet. 2002. PMID: 12165567

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Analysis of the cytosolic proteome in a cell culture model of familial amyotrophic lateral sclerosis reveals alterations to the proteasome, antioxidant defenses, and nitric oxide synthetic pathways.

Allen S, Heath PR, Kirby J, Wharton SB, Cookson MR, Menzies FM, Banks RE, Shaw PJ. Allen S, et al. Among authors: kirby j. J Biol Chem. 2003 Feb 21;278(8):6371-83. doi: 10.1074/jbc.M209915200. Epub 2002 Dec 9. J Biol Chem. 2003. PMID: 12475980

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No association with common Caucasian genotypes in exons 8, 13 and 14 of the human cytoplasmic dynein heavy chain gene (DNCHC1) and familial motor neuron disorders.

Ahmad-Annuar A, Shah P, Hafezparast M, Hummerich H, Witherden AS, Morrison KE, Shaw PJ, Kirby J, Warner TT, Crosby A, Proukakis C, Wilkinson P, Orrell RW, Bradley L, Martin JE, Fisher EM. Ahmad-Annuar A, et al. Among authors: kirby j. Amyotroph Lateral Scler Other Motor Neuron Disord. 2003 Sep;4(3):150-7. doi: 10.1080/14660820310011737. Amyotroph Lateral Scler Other Motor Neuron Disord. 2003. PMID: 13129801

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Screening of the regulatory and coding regions of vascular endothelial growth factor in amyotrophic lateral sclerosis.

Brockington A, Kirby J, Eggitt D, Schofield E, Morris C, Lewis CE, Ince PG, Shaw PJ. Brockington A, et al. Among authors: kirby j. Neurogenetics. 2005 May;6(2):101-4. doi: 10.1007/s10048-004-0201-4. Epub 2005 Mar 18. Neurogenetics. 2005. PMID: 15776280 No abstract available.

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Mutant SOD1 alters the motor neuronal transcriptome: implications for familial ALS.

Kirby J, Halligan E, Baptista MJ, Allen S, Heath PR, Holden H, Barber SC, Loynes CA, Wood-Allum CA, Lunec J, Shaw PJ. Kirby J, et al. Brain. 2005 Jul;128(Pt 7):1686-706. doi: 10.1093/brain/awh503. Epub 2005 May 4. Brain. 2005. PMID: 15872021

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Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen.

Wood-Allum CA, Barber SC, Kirby J, Heath P, Holden H, Mead R, Higginbottom A, Allen S, Beaujeux T, Alexson SE, Ince PG, Shaw PJ. Wood-Allum CA, et al. Among authors: kirby j. Brain. 2006 Jul;129(Pt 7):1693-709. doi: 10.1093/brain/awl118. Epub 2006 May 15. Brain. 2006. PMID: 16702190

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Clinical features of hereditary spastic paraplegia due to spastin mutation.

McDermott CJ, Burness CE, Kirby J, Cox LE, Rao DG, Hewamadduma C, Sharrack B, Hadjivassiliou M, Chinnery PF, Dalton A, Shaw PJ; UK and Irish HSP Consortium. McDermott CJ, et al. Among authors: kirby j. Neurology. 2006 Jul 11;67(1):45-51. doi: 10.1212/01.wnl.0000223315.62404.00. Neurology. 2006. PMID: 16832076

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Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations.

Mackenzie IR, Bigio EH, Ince PG, Geser F, Neumann M, Cairns NJ, Kwong LK, Forman MS, Ravits J, Stewart H, Eisen A, McClusky L, Kretzschmar HA, Monoranu CM, Highley JR, Kirby J, Siddique T, Shaw PJ, Lee VM, Trojanowski JQ. Mackenzie IR, et al. Among authors: kirby j. Ann Neurol. 2007 May;61(5):427-34. doi: 10.1002/ana.21147. Ann Neurol. 2007. PMID: 17469116

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Mutations in VAPB are not associated with sporadic ALS.

Kirby J, Hewamadduma CA, Hartley JA, Nixon HC, Evans H, Wadhwa RR, Kershaw C, Ince PG, Shaw PJ. Kirby J, et al. Neurology. 2007 May 29;68(22):1951-3. doi: 10.1212/01.wnl.0000263195.50981.a6. Neurology. 2007. PMID: 17536055 No abstract available.

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